OBJECTIVE: Pronounced weight loss after bariatric surgery was demonstrated to have significant beneficial effects on surrogates of early atherosclerosis. The aim of this prospective examination was to investigate whether these improvements of endothelial function and vascular structure are persistent in the long-term. DESIGN AND METHODS: A total of 52 obese adults were examined before and 5 years after bariatric surgery. Carotid intima media thickness (IMT), brachial flow-mediated dilation (FMD), abdominal fat distribution, and metabolic parameters were determined. Additional 18 months data were available from 27 patients. RESULTS: After 5 years, mean weight loss ± SD of 25% ± 12 in all subjects was accompanied by known improvements in metabolism. Change in IMT was -0.02 mm ± 0.007, whereas FMD improved by +1.5% ± 0.5. In the subgroup IMT decreased by 0.04 mm ± 0.06 within the first 18 months, whereas no significant change was observed between 18 month and 5 years. FMD improved by 3.8% ± 0.6 after 18 months followed by a nonsignificant decrease of -1.4% ± 0.9. CONCLUSIONS: These long-term results demonstrate that bariatric surgery-induced weight loss improves both functional and structural markers of early atherosclerosis providing further evidence for the beneficial effects of weight loss on obesity-associated alterations of the vasculature.
OBJECTIVE: Pronounced weight loss after bariatric surgery was demonstrated to have significant beneficial effects on surrogates of early atherosclerosis. The aim of this prospective examination was to investigate whether these improvements of endothelial function and vascular structure are persistent in the long-term. DESIGN AND METHODS: A total of 52 obese adults were examined before and 5 years after bariatric surgery. Carotid intima media thickness (IMT), brachial flow-mediated dilation (FMD), abdominal fat distribution, and metabolic parameters were determined. Additional 18 months data were available from 27 patients. RESULTS: After 5 years, mean weight loss ± SD of 25% ± 12 in all subjects was accompanied by known improvements in metabolism. Change in IMT was -0.02 mm ± 0.007, whereas FMD improved by +1.5% ± 0.5. In the subgroup IMT decreased by 0.04 mm ± 0.06 within the first 18 months, whereas no significant change was observed between 18 month and 5 years. FMD improved by 3.8% ± 0.6 after 18 months followed by a nonsignificant decrease of -1.4% ± 0.9. CONCLUSIONS: These long-term results demonstrate that bariatric surgery-induced weight loss improves both functional and structural markers of early atherosclerosis providing further evidence for the beneficial effects of weight loss on obesity-associated alterations of the vasculature.
Authors: R Lupoli; M N D Di Minno; C Guidone; C Cefalo; B Capaldo; G Riccardi; G Mingrone Journal: Int J Obes (Lond) Date: 2015-09-21 Impact factor: 5.095
Authors: Pilar Cobeta; Alvaro Osorio; Marta Cuadrado-Ayuso; Francisca García-Moreno; David Pestaña; Julio Galindo; José I Botella-Carretero Journal: Obes Surg Date: 2020-03 Impact factor: 4.129
Authors: G Lambert; Marcelo Miranda de Oliveira Lima; A C Felici; J C Pareja; A C J Vasques; F S Novaes; S Rodovalho; F F P Hirsch; J R Matos-Souza; Élinton A Chaim; B Geloneze Journal: Obes Surg Date: 2018-01 Impact factor: 4.129
Authors: Maurizio De Luca; Luigi Angrisani; Jacques Himpens; Luca Busetto; Nicola Scopinaro; Rudolf Weiner; Alberto Sartori; Christine Stier; Muffazal Lakdawala; Aparna G Bhasker; Henry Buchwald; John Dixon; Sonja Chiappetta; Hans-Christian Kolberg; Gema Frühbeck; David B Sarwer; Michel Suter; Emanuele Soricelli; Mattias Blüher; Ramon Vilallonga; Arya Sharma; Scott Shikora Journal: Obes Surg Date: 2016-08 Impact factor: 4.129
Authors: Frederik H W Jonker; Vera A A van Houten; Leontine H Wijngaarden; René A Klaassen; André A E A de Smet; André Niezen; Lodewijk J D M Schelfhout; Tobias A Bruning; Erwin van der Harst Journal: Obes Surg Date: 2018-04 Impact factor: 4.129
Authors: Hassan Kahal; Ahmed Aburima; Tamas Ungvari; Alan S Rigby; Anne M Coady; Rebecca V Vince; Ramzi A Ajjan; Eric S Kilpatrick; Khalid M Naseem; Stephen L Atkin Journal: BMC Endocr Disord Date: 2015-04-02 Impact factor: 2.763
Authors: Noyan Gokce; Shakun Karki; Alyssa Dobyns; Elaina Zizza; Emily Sroczynski; Joseph N Palmisano; Celestina Mazzotta; Naomi M Hamburg; Luise I Pernar; Brian Carmine; Cullen O Carter; Michael LaValley; Donald T Hess; Caroline M Apovian; Melissa G Farb Journal: JAMA Netw Open Date: 2021-07-01