Literature DB >> 23512428

Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer.

Evren Fidan1, Ahmet Mentese, Feyyaz Ozdemir, Orhan Deger, Halil Kavgaci, S Caner Karahan, Fazil Aydin.   

Abstract

This study was intended to evaluate the prognostic and diagnostic significance of carbonic anhydrase IX (CA IX) and soluble urokinase plasminogen activator receptor (suPAR) levels in gastric cancer patients. CA IX and suPAR were analyzed from serum and plasma samples of gastric cancer patients. Fifty patients and 34 controls were enrolled. CA IX and suPAR levels were statistically significantly higher in the patient group (patient; 182.5 ± 212.4, control; 47.3 ± 32, P = 0.0001 and patient; 5.74 ± 5.3, control; 2.27 ± 0.77, P = 0.0001, respectively). CA IX and suPAR levels were higher in metastatic subjects (metastatic; 227.1 ± 273.5, non-metastatic; 147.4 ± 144.1, P > 0.05). Prognosis was worse in the patient group with elevated suPAR. CA IX and especially suPAR are correlated with the presence and stage of the disease. High suPAR levels indicate a poorer prognosis in gastric cancer patients.

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Year:  2013        PMID： 23512428     DOI： 10.1007/s12032-013-0540-9

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  16 in total

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  17 in total

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Journal:  J Immunol       Date:  2014-05-07       Impact factor: 5.422

3.  Significance of peripheral neutrophil-lymphocyte ratio among gastric cancer patients and construction of a treatment-predictive model: a study based on 1131 cases.

Authors:  A-Man Xu; Lei Huang; Liang Zhu; Zhi-Jian Wei
Journal:  Am J Cancer Res       Date:  2014-03-01       Impact factor: 6.166

4.  Seroprevalence of Helicobacter pylori/CagA Antibodies in Guatemalan Gastric Cancer Patients: Association of Seropositivity with Increased Plasma Levels of Pepsinogens but not Soluble Urokinase Plasminogen Activator Receptor.

Authors:  Rafael Fernandez-Botran; Irmgardt Alicia Wellmann; Clas Une; Ericka Méndez-Chacón; Elisa Hernández de Rodas; Bikash Bhandari; Carmen I Villagrán de Tercero
Journal:  Am J Trop Med Hyg       Date:  2020-04-16       Impact factor: 2.345

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Review 7.  Cancer metabolism: New insights into classic characteristics.

Authors:  Yasumasa Kato; Toyonobu Maeda; Atsuko Suzuki; Yuh Baba
Journal:  Jpn Dent Sci Rev       Date:  2017-09-29

8.  Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo.

Authors:  Siao-Syun Guan; Chun-Chia Cheng; Ai-Sheng Ho; Chia-Chi Wang; Tsai-Yueh Luo; Tse-Zung Liao; Jungshan Chang; Cheng-Tien Wu; Shing-Hwa Liu
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Journal:  Oncotarget       Date:  2018-06-05

10.  Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis.

Authors:  Fabian Finkelmeier; Özge Canli; Kai-Henrik Peiffer; Dirk Walter; Andrea Tal; Christine Koch; Ursula Pession; Johannes Vermehren; Jörg Trojan; Stefan Zeuzem; Albrecht Piiper; Florian R Greten; Georgios Grammatikos; Oliver Waidmann
Journal:  PLoS One       Date:  2018-07-16       Impact factor: 3.240
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