BACKGROUND:Functional magnetic resonance imaging (fMRI) has become part of routine brain mapping in patients with epilepsy or tumor undergoing resective surgery. However, robust localization of crucial functional areas is required. OBJECTIVE: To establish a simple, short fMRI task that reliably localizes crucial language areas in individual patients who undergo respective surgery. METHODS:fMRI was measured during an 8-minute auditory semantic decision task in 28 healthy controls and 35 consecutive patients who had focal epilepsy or a brain tumor. Nineteen underwent resective surgery. Group and individual analyses were performed. Results in patients were compared with postsurgical language outcome and electrocortical stimulation when available. RESULTS:fMRI activations concordant with the anterior and posterior language areas were found in 96% and 89% of the controls, respectively. The anterior and posterior language areas were both activated in 93% of the patients. These results were concordant with electrocortical stimulation results in 5 patients. Transient postsurgical language deficits were found in 2 patients in whom surgery was performed in the vicinity of the fMRI activations or who had postsurgical complications implicating areas of fMRI activations. CONCLUSION: The proposed fast fMRI language protocol reliably localized the most relevant language areas in individual subjects. It appears to be a valuable complementary tool for surgical planning of epileptogenic foci and of brain tumors.
RCT Entities:
BACKGROUND: Functional magnetic resonance imaging (fMRI) has become part of routine brain mapping in patients with epilepsy or tumor undergoing resective surgery. However, robust localization of crucial functional areas is required. OBJECTIVE: To establish a simple, short fMRI task that reliably localizes crucial language areas in individual patients who undergo respective surgery. METHODS: fMRI was measured during an 8-minute auditory semantic decision task in 28 healthy controls and 35 consecutive patients who had focal epilepsy or a brain tumor. Nineteen underwent resective surgery. Group and individual analyses were performed. Results in patients were compared with postsurgical language outcome and electrocortical stimulation when available. RESULTS: fMRI activations concordant with the anterior and posterior language areas were found in 96% and 89% of the controls, respectively. The anterior and posterior language areas were both activated in 93% of the patients. These results were concordant with electrocortical stimulation results in 5 patients. Transient postsurgical language deficits were found in 2 patients in whom surgery was performed in the vicinity of the fMRI activations or who had postsurgical complications implicating areas of fMRI activations. CONCLUSION: The proposed fast fMRI language protocol reliably localized the most relevant language areas in individual subjects. It appears to be a valuable complementary tool for surgical planning of epileptogenic foci and of brain tumors.
Authors: Lok Wa Laura Leung; Prashin Unadkat; Melina More Bertotti; Wenya Linda Bi; Walid Ibn Essayed; Adomas Bunevicius; Vamsidhar Chavakula; Laura Rigolo; Luca Fumagalli; Ziyun Tie; Alexandra J Golby; Yanmei Tie Journal: J Neuroimaging Date: 2020-02-10 Impact factor: 2.486
Authors: Frédéric Grouiller; João Jorge; Francesca Pittau; Wietske van der Zwaag; Giannina Rita Iannotti; Christoph Martin Michel; Serge Vulliémoz; Maria Isabel Vargas; François Lazeyras Journal: MAGMA Date: 2016-03-05 Impact factor: 2.310
Authors: Diana Cristina Ghinda; Ben Lambert; Junfeng Lu; Ning Jiang; Eve Tsai; Adam Sachs; Jin-Song Wu; Georg Northoff Journal: Front Oncol Date: 2021-02-23 Impact factor: 6.244
Authors: Mary Katherine Montgomery; Sharon H Kim; Athanassios Dovas; Hanzhi T Zhao; Alexander R Goldberg; Weihao Xu; Alexis J Yagielski; Morgan K Cambareri; Kripa B Patel; Angeliki Mela; Nelson Humala; David N Thibodeaux; Mohammed A Shaik; Ying Ma; Jack Grinband; Daniel S Chow; Catherine Schevon; Peter Canoll; Elizabeth M C Hillman Journal: Cell Rep Date: 2020-04-14 Impact factor: 9.423