Literature DB >> 23511713

A map of Alzheimer's disease-signaling pathways: a hope for drug target discovery.

S Ogishima1, S Mizuno, M Kikuchi, A Miyashita, R Kuwano, H Tanaka, J Nakaya.   

Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD-related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD-signaling pathways and networks.

Entities:  

Mesh：

Year:  2013        PMID： 23511713     DOI： 10.1038/clpt.2013.37

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  11 in total

1.  Sex-specific patterns and differences in dementia and Alzheimer's disease using informatics approaches.

Authors:  Jay Geronimo Ronquillo; Merritt Rachel Baer; William T Lester
Journal:  J Women Aging       Date:  2016-04-22

2.  A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect.

Authors:  Erfan Younesi; Martin Hofmann-Apitius
Journal:  J Transl Med       Date:  2013-07-26       Impact factor: 5.531

Review 3.  Current advances in systems and integrative biology.

Authors:  Scott W Robinson; Marco Fernandes; Holger Husi
Journal:  Comput Struct Biotechnol J       Date:  2014-08-27       Impact factor: 7.271

4.  esyN: network building, sharing and publishing.

Authors:  Daniel M Bean; Joshua Heimbach; Lorenzo Ficorella; Gos Micklem; Stephen G Oliver; Giorgio Favrin
Journal:  PLoS One       Date:  2014-09-02       Impact factor: 3.240

5.  Profiling of Human Molecular Pathways Affected by Retrotransposons at the Level of Regulation by Transcription Factor Proteins.

Authors:  Daniil Nikitin; Dmitry Penzar; Andrew Garazha; Maxim Sorokin; Victor Tkachev; Nicolas Borisov; Alexander Poltorak; Vladimir Prassolov; Anton A Buzdin
Journal:  Front Immunol       Date:  2018-01-30       Impact factor: 7.561

Review 6.  Clinical Trials for Disease-Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future.

Authors:  Jeffrey Cummings; Aaron Ritter; Kate Zhong
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

7.  Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.

Authors:  Jeffrey R Petrella; Wenrui Hao; Adithi Rao; P Murali Doraiswamy
Journal:  Comput Math Methods Med       Date:  2019-02-03       Impact factor: 2.238

8.  Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease.

Authors:  Satoshi Mizuno; Soichi Ogishima; Kazuyuki Kitatani; Masataka Kikuchi; Hiroshi Tanaka; Nobuo Yaegashi; Jun Nakaya
Journal:  PLoS One       Date:  2016-02-05       Impact factor: 3.240

Review 9.  Lessons Learned from Alzheimer Disease: Clinical Trials with Negative Outcomes.

Authors:  Jeffrey Cummings
Journal:  Clin Transl Sci       Date:  2017-08-02       Impact factor: 4.689

10.  Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Authors:  Liu Shi; Sarah Westwood; Alison L Baird; Laura Winchester; Valerija Dobricic; Fabian Kilpert; Shengjun Hong; Andre Franke; Abdul Hye; Nicholas J Ashton; Angharad R Morgan; Isabelle Bos; Stephanie J B Vos; Noel J Buckley; Mara Ten Kate; Philip Scheltens; Rik Vandenberghe; Silvy Gabel; Karen Meersmans; Sebastiaan Engelborghs; Ellen E De Roeck; Kristel Sleegers; Giovanni B Frisoni; Olivier Blin; Jill C Richardson; Régis Bordet; José L Molinuevo; Lorena Rami; Anders Wallin; Petronella Kettunen; Magda Tsolaki; Frans Verhey; Alberto Lleó; Daniel Alcolea; Julius Popp; Gwendoline Peyratout; Pablo Martinez-Lage; Mikel Tainta; Peter Johannsen; Charlotte E Teunissen; Yvonne Freund-Levi; Lutz Frölich; Cristina Legido-Quigley; Frederik Barkhof; Kaj Blennow; Henrik Zetterberg; Susan Baker; B Paul Morgan; Johannes Streffer; Pieter Jelle Visser; Lars Bertram; Simon Lovestone; Alejo J Nevado-Holgado
Journal:  Alzheimers Dement       Date:  2019-09-05       Impact factor: 21.566
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.