BACKGROUND: A sedentary lifestyle is a major risk factor for cardiovascular and thrombotic complications. While habitual endurance activity will reduce the risk of these adverse events, the influence of habitual resistance exercise is less clear. This study examined coagulation and fibrinolytic responses to an acute exhaustive resistance exercise test (AERET) in both resistance-trained (RT, min 2 yr, 5 men and 5 women) and untrained (UT, 5 men and 5 women) subjects. METHODS: The AERET consisted of six sets of 10 repetitions of squats at 80% of 1-repetition maximum. Venous blood was collected pre-exercise, immediate post exercise (IP), and +15, +60, and +120 minutes post exercise. RESULTS: Compared to UT, RT exhibited a lower capacity to form a clot as seen by activated partial Thromboplastin time (aPTT) integrated area under the curve over time (iAUC) levels, lower pre-exercise and 120 min post-exercise plasminogen activator inhibitor -1 (PAI-1) activity, and higher tissue plasminogen activator (tPA) activity immediately post-exercise. There were no significant differences between RT and UT for fibrinogen, prothrombin fragment 1+2 (PTF 1+2), and thrombin-antithrombin complexes (TAT). CONCLUSION: These results suggest that habitual resistance exercise training may provide an enhanced fibrinolytic state.
BACKGROUND: A sedentary lifestyle is a major risk factor for cardiovascular and thrombotic complications. While habitual endurance activity will reduce the risk of these adverse events, the influence of habitual resistance exercise is less clear. This study examined coagulation and fibrinolytic responses to an acute exhaustive resistance exercise test (AERET) in both resistance-trained (RT, min 2 yr, 5 men and 5 women) and untrained (UT, 5 men and 5 women) subjects. METHODS: The AERET consisted of six sets of 10 repetitions of squats at 80% of 1-repetition maximum. Venous blood was collected pre-exercise, immediate post exercise (IP), and +15, +60, and +120 minutes post exercise. RESULTS: Compared to UT, RT exhibited a lower capacity to form a clot as seen by activated partial Thromboplastin time (aPTT) integrated area under the curve over time (iAUC) levels, lower pre-exercise and 120 min post-exercise plasminogen activator inhibitor -1 (PAI-1) activity, and higher tissue plasminogen activator (tPA) activity immediately post-exercise. There were no significant differences between RT and UT for fibrinogen, prothrombin fragment 1+2 (PTF 1+2), and thrombin-antithrombin complexes (TAT). CONCLUSION: These results suggest that habitual resistance exercise training may provide an enhanced fibrinolytic state.
Authors: Brent C Creighton; Brian R Kupchak; Juan C Aristizabal; Shawn D Flanagan; Courtenay Dunn-Lewis; Brittanie M Volk; Brett A Comstock; Jeff S Volek; David R Hooper; Tunde K Szivak; Carl M Maresh; William J Kraemer Journal: Eur J Appl Physiol Date: 2013-04-30 Impact factor: 3.078
Authors: Emma Kate Zadow; Daniel William Taylor Wundersitz; Diane Louise Hughes; Murray John Adams; Michael Ian Charles Kingsley; Hilary Anne Blacklock; Sam Shi Xuan Wu; Amanda Clare Benson; Frédéric Dutheil; Brett Ashley Gordon Journal: Semin Thromb Hemost Date: 2020-09-03 Impact factor: 4.180
Authors: Karina T Kasawara; Tiziana Cotechini; Shannyn K Macdonald-Goodfellow; Fernanda G Surita; João L Pinto E Silva; Chandrakant Tayade; Maha Othman; Terence R S Ozolinš; Charles H Graham Journal: PLoS One Date: 2016-04-28 Impact factor: 3.240
Authors: James E Waha; Nandu Goswami; Axel Schlagenhauf; Bettina Leschnik; Martin Koestenberger; Gilbert Reibnegger; Regina E Roller; Helmut Hinghofer-Szalkay; Gerhard Cvirn Journal: Medicine (Baltimore) Date: 2015-09 Impact factor: 1.817