OBJECTIVE: The aim of this study was to evaluate and compare the activity of oral mouthwashes against biofilm forms of MRSA isolated from the oral cavity and the bloodstream. STUDY DESIGN: The time-kill kinetics efficacy of 7 over-the-counter mouthwashes were tested against 28 clinical MRSA biofilm isolates for 0.5, 1 and 2 min. RESULTS: Treatments of MRSA biofilms formed by oral and bloodstream isolates were not significantly different, with mouthwashes displaying a rapid and modest anti-biofilm effect. None of the biofilm isolates were completely eradicated by the compounds tested, with a maximal killing of only approximately 70% shown by Corsodyl and Peroxyl. Maximum activity of all compounds tested was observed after 0.5 min. Fluorigard showed the poorest overall activity (57% reduction). CONCLUSIONS: MRSA colonize the oral cavity, and are more prevalent in institutionalized persons and the elderly. Over-the-counter mouthwashes are ineffective at killing MRSA biofilms, which has infection control implications.
OBJECTIVE: The aim of this study was to evaluate and compare the activity of oral mouthwashes against biofilm forms of MRSA isolated from the oral cavity and the bloodstream. STUDY DESIGN: The time-kill kinetics efficacy of 7 over-the-counter mouthwashes were tested against 28 clinical MRSA biofilm isolates for 0.5, 1 and 2 min. RESULTS: Treatments of MRSA biofilms formed by oral and bloodstream isolates were not significantly different, with mouthwashes displaying a rapid and modest anti-biofilm effect. None of the biofilm isolates were completely eradicated by the compounds tested, with a maximal killing of only approximately 70% shown by Corsodyl and Peroxyl. Maximum activity of all compounds tested was observed after 0.5 min. Fluorigard showed the poorest overall activity (57% reduction). CONCLUSIONS:MRSA colonize the oral cavity, and are more prevalent in institutionalized persons and the elderly. Over-the-counter mouthwashes are ineffective at killing MRSA biofilms, which has infection control implications.
Authors: Xiaojun Mao; David L Auer; Wolfgang Buchalla; Karl-Anton Hiller; Tim Maisch; Elmar Hellwig; Ali Al-Ahmad; Fabian Cieplik Journal: Antimicrob Agents Chemother Date: 2020-07-22 Impact factor: 5.191
Authors: Leighann Sherry; Emma Millhouse; David F Lappin; Colin Murray; Shauna Culshaw; Christopher J Nile; Gordon Ramage Journal: BMC Oral Health Date: 2013-09-24 Impact factor: 2.757
Authors: Lamprini Karygianni; Ali Al-Ahmad; Aikaterini Argyropoulou; Elmar Hellwig; Annette C Anderson; Alexios L Skaltsounis Journal: Front Microbiol Date: 2016-01-14 Impact factor: 5.640