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Literature DB >> 23510681

The journey of the organelle: teamwork and regulation in intracellular transport.

Kari Barlan¹, Molly J Rossow, Vladimir I Gelfand.

Abstract

Specific subsets of biochemical reactions in eukaryotic cells are restricted to individual membrane compartments, or organelles. Cells, therefore, face the monumental task of moving the products of those reactions between individual organelles. Because of the high density of the cytoplasm and the large size of membrane organelles, simple diffusion is grossly insufficient for this task. Proper trafficking between membrane organelles thus relies on cytoskeletal elements and the activity of motor proteins, that act both in transport of membrane compartments and as tethering agents to ensure their proper distribution and to facilitate organelle interactions.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Molecular Motor Proteins

Year: 2013 PMID： 23510681 PMCID： PMC3723706 DOI： 10.1016/j.ceb.2013.02.018

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

33 in total

1. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.

Authors: Andrey Efimov; Alexey Kharitonov; Nadia Efimova; Jadranka Loncarek; Paul M Miller; Natalia Andreyeva; Paul Gleeson; Niels Galjart; Ana R R Maia; Ian X McLeod; John R Yates; Helder Maiato; Alexey Khodjakov; Anna Akhmanova; Irina Kaverina
Journal: Dev Cell Date: 2007-06 Impact factor: 12.270

The journey of the organelle: teamwork and regulation in intracellular transport.

1. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.

2. In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.

3. LIS1 and NudE induce a persistent dynein force-producing state.

4. The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors.

5. Microtubule acetylation promotes kinesin-1 binding and transport.

6. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility.

7. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent.

8. Single molecule imaging reveals differences in microtubule track selection between Kinesin motors.

9. Opposite-polarity motors activate one another to trigger cargo transport in live cells.

10. Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.

1. Transport efficiency of membrane-anchored kinesin-1 motors depends on motor density and diffusivity.

Review 2. Germ cell transport across the seminiferous epithelium during spermatogenesis.

3. Motor mutants bring wild-type motors to a halt stochastically.

4. Delineating cooperative responses of processive motors in living cells.

5. High content organelle trafficking enables disease state profiling as powerful tool for disease modelling.

Review 6. The delivery of therapeutic oligonucleotides.

Review 7. Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles.

Review 8. Cellular uptake and intracellular trafficking of oligonucleotides.

Review 9. Processive cytoskeletal motors studied with single-molecule fluorescence techniques.

10. Engineered Tug-of-War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport In Vivo.