AIM AND METHODS: Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure-activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro-organisms. RESULTS: 2,4-Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram-negative and Gram-positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin-susceptible Staphylococcus aureus. MRSA was inhibited by 2,4-dihydroxybenzoic, vanillic, syringic (MICs = 0.5 mg ml(-1) ) and p-coumaric (MIC = 1 mg ml(-1) ) acids, while these compounds at the same concentrations had no inhibitory effects against methicillin-susceptible Staph. aureus. CONCLUSIONS: The presence of carboxylic acid (COOH), two hydroxyl (OH) groups in para and ortho positions of the benzene ring and also a methoxyl (OCH3 ) group in the meta position seems to be important for anti-MRSA activity. SIGNIFICANCE AND IMPACT OF THE STUDY: Phenolic compounds could be used as antimicrobial agents, namely against some micro-organisms resistant to commercial antibiotics.
AIM AND METHODS: Although the antimicrobial activity of extracts from several mushroom species has been reported, studies with the individual compounds present in that extracts are scarce. Herein, the antimicrobial activity of different phenolic compounds identified and quantified in mushroom species from all over the world was evaluated. Furthermore, a structure-activity relationship (SAR) analysis and molecular docking studies were performed, in order to provide insights into the mechanism of action of potential antimicrobial drugs for resistant micro-organisms. RESULTS:2,4-Dihydroxybenzoic and protocatechuic acids were the phenolic compounds with higher activity against the majority of Gram-negative and Gram-positive bacteria. Furthermore, phenolic compounds inhibited more MRSA than methicillin-susceptible Staphylococcus aureus. MRSA was inhibited by 2,4-dihydroxybenzoic, vanillic, syringic (MICs = 0.5 mg ml(-1) ) and p-coumaric (MIC = 1 mg ml(-1) ) acids, while these compounds at the same concentrations had no inhibitory effects against methicillin-susceptible Staph. aureus. CONCLUSIONS: The presence of carboxylic acid (COOH), two hydroxyl (OH) groups in para and ortho positions of the benzene ring and also a methoxyl (OCH3 ) group in the meta position seems to be important for anti-MRSA activity. SIGNIFICANCE AND IMPACT OF THE STUDY: Phenolic compounds could be used as antimicrobial agents, namely against some micro-organisms resistant to commercial antibiotics.
Authors: Emiliana Tortorella; Rosa Giugliano; Marleen De Troch; Bruno Vlaeminck; Gercende Courtois de Viçose; Donatella de Pascale Journal: Mar Biotechnol (NY) Date: 2021-10-29 Impact factor: 3.619
Authors: Tomasz Szostek; Daniel Szulczyk; Jolanta Szymańska-Majchrzak; Michał Koliński; Sebastian Kmiecik; Dagmara Otto-Ślusarczyk; Aleksandra Zawodnik; Eliza Rajkowska; Kinga Chaniewicz; Marta Struga; Piotr Roszkowski Journal: Int J Mol Sci Date: 2022-06-13 Impact factor: 6.208