BACKGROUND: Neuroendocrine tumors of the thyroid encompass a wide differential diagnosis. The most common is medullary thyroid carcinoma. One must consider other possibilities when a neuroendocrine thyroid tumor is calcitonin negative. We report 2 cases of Ewing sarcoma of the thyroid and discuss the differential diagnosis and workup of a calcitonin-negative neuroendocrine tumor of the thyroid. METHODS/ RESULTS: This is a retrospective review of 2 patients diagnosed with Ewing sarcoma of the thyroid and a review of the literature. CONCLUSIONS: Ewing sarcoma of the thyroid is an exceedingly rare diagnosis, but should be included in the differential diagnosis for a thyroidal neuroendocrine lesion (especially in the absence of calcitonin). The use and interpretation of immunohistochemistry (IHC) and fluorescent in situ hybridization are essential in making the correct diagnosis.
BACKGROUND:Neuroendocrine tumors of the thyroid encompass a wide differential diagnosis. The most common is medullary thyroid carcinoma. One must consider other possibilities when a neuroendocrine thyroid tumor is calcitonin negative. We report 2 cases of Ewing sarcoma of the thyroid and discuss the differential diagnosis and workup of a calcitonin-negative neuroendocrine tumor of the thyroid. METHODS/ RESULTS: This is a retrospective review of 2 patients diagnosed with Ewing sarcoma of the thyroid and a review of the literature. CONCLUSIONS:Ewing sarcoma of the thyroid is an exceedingly rare diagnosis, but should be included in the differential diagnosis for a thyroidal neuroendocrine lesion (especially in the absence of calcitonin). The use and interpretation of immunohistochemistry (IHC) and fluorescent in situ hybridization are essential in making the correct diagnosis.
Authors: G Oliveira; A Polónia; J M Cameselle-Teijeiro; D Leitão; S Sapia; M Sobrinho-Simões; C Eloy Journal: Virchows Arch Date: 2017-02-24 Impact factor: 4.064
Authors: Paweł Kabata; Sonia Kaniuka-Jakubowska; Wanda Kabata; Joanna Lakomy; Wojciech Biernat; Krzysztof Sworczak; Janusz Jaśkiewicz; Maciej Świerblewski Journal: Front Endocrinol (Lausanne) Date: 2017-10-27 Impact factor: 5.555
Authors: Amanda H Seipel; Hiba Mechahougui; Nicolas Mach; Frédéric Triponez; William C Faquin; Claudio De Vito Journal: Head Neck Pathol Date: 2021-07-26