| Literature DB >> 23507470 |
Meghan Karuturi1, Chitra Hosing, Michelle Fanale, L Jeffrey Medeiros, Amin M Alousi, Marcos J de Lima, Muzaffar H Qazilbash, Partow Kebriaei, Anas Younes, Issa Khouri, Borje S Andersson, Richard Champlin, Paolo Anderlini, Uday Popat.
Abstract
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a distinct subtype of Hodgkin lymphoma that is characterized by unique clinical presentation, histological appearance, and indolent disease course. The recurrent nature of disease provides an opportunity to examine the role of stem cell transplantation in its management. We report here a single-center experience of 26 patients with relapsed NLPHL treated with high-dose chemotherapy and autologous stem cell transplantation between 1990 and 2008. With a median follow-up of 50 months (range, 2-138 months), the 5-year overall and event-free survival were 76% (SE 10%) and 69% (SE 10%), respectively. Our data suggest that high-dose chemotherapy and autologous transplantation should be considered as an option for patients with relapsed NLPHL.Entities:
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Year: 2013 PMID： 23507470 PMCID： PMC4411554 DOI： 10.1016/j.bbmt.2013.03.008
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN： 1083-8791 Impact factor: 5.742