Literature DB >> 23507357

Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.

Rachael J Bloom1, Anna K Kähler, Ann L Collins, Guanhua Chen, Tyrone D Cannon, Christina Hultman, Patrick F Sullivan.   

Abstract

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.
Copyright © 2013 Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23507357      PMCID： PMC3650833          DOI： 10.1016/j.schres.2013.02.021

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  12 in total

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Journal:  Twin Res Hum Genet       Date:  2006-12       Impact factor: 1.587

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Authors:  Shinji Ono; Akira Imamura; Shinya Tasaki; Naohiro Kurotaki; Hiroki Ozawa; Koh-ichiro Yoshiura; Yuji Okazaki
Journal:  Twin Res Hum Genet       Date:  2010-10       Impact factor: 1.587

4.  Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.

Authors:  Carl E G Bruder; Arkadiusz Piotrowski; Antoinet A C J Gijsbers; Robin Andersson; Stephen Erickson; Teresita Diaz de Ståhl; Uwe Menzel; Johanna Sandgren; Desiree von Tell; Andrzej Poplawski; Michael Crowley; Chiquito Crasto; E Christopher Partridge; Hemant Tiwari; David B Allison; Jan Komorowski; Gert-Jan B van Ommen; Dorret I Boomsma; Nancy L Pedersen; Johan T den Dunnen; Karin Wirdefeldt; Jan P Dumanski
Journal:  Am J Hum Genet       Date:  2008-02-14       Impact factor: 11.025

5.  Large-scale zygosity testing using single nucleotide polymorphisms.

Authors:  Ulf Hannelius; Loreana Gherman; Ville-Veikko Mäkelä; Astrid Lindstedt; Marco Zucchelli; Camilla Lagerberg; Gunnel Tybring; Juha Kere; Cecilia M Lindgren
Journal:  Twin Res Hum Genet       Date:  2007-08       Impact factor: 1.587

6.  Offspring of monozygotic twins discordant for schizophrenia.

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7.  Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.

Authors:  Patrick F Sullivan; Kenneth S Kendler; Michael C Neale
Journal:  Arch Gen Psychiatry       Date:  2003-12

8.  Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.

Authors:  Sergio E Baranzini; Joann Mudge; Jennifer C van Velkinburgh; Pouya Khankhanian; Irina Khrebtukova; Neil A Miller; Lu Zhang; Andrew D Farmer; Callum J Bell; Ryan W Kim; Gregory D May; Jimmy E Woodward; Stacy J Caillier; Joseph P McElroy; Refujia Gomez; Marcelo J Pando; Leonda E Clendenen; Elena E Ganusova; Faye D Schilkey; Thiruvarangan Ramaraj; Omar A Khan; Jim J Huntley; Shujun Luo; Pui-Yan Kwok; Thomas D Wu; Gary P Schroth; Jorge R Oksenberg; Stephen L Hauser; Stephen F Kingsmore
Journal:  Nature       Date:  2010-04-29       Impact factor: 49.962

9.  Ontogenetic de novo copy number variations (CNVs) as a source of genetic individuality: studies on two families with MZD twins for schizophrenia.

Authors:  Sujit Maiti; Kiran Halagur Bhoge Gowda Kumar; Christina A Castellani; Richard O'Reilly; Shiva M Singh
Journal:  PLoS One       Date:  2011-03-02       Impact factor: 3.240

Review 10.  Challenges and standards in integrating surveys of structural variation.

Authors:  Stephen W Scherer; Charles Lee; Ewan Birney; David M Altshuler; Evan E Eichler; Nigel P Carter; Matthew E Hurles; Lars Feuk
Journal:  Nat Genet       Date:  2007-07       Impact factor: 38.330
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  8 in total

Review 1.  Genomic structural variation in affective, anxiety, and stress-related disorders.

Authors:  Shinji Ono; Katharina Domschke; Jürgen Deckert
Journal:  J Neural Transm (Vienna)       Date:  2014-09-13       Impact factor: 3.575

2.  Assessment of copy number variations in the brain genome of schizophrenia patients.

Authors:  Miwako Sakai; Yuichiro Watanabe; Toshiyuki Someya; Kazuaki Araki; Masako Shibuya; Kazuhiro Niizato; Kenichi Oshima; Yasuto Kunii; Hirooki Yabe; Junya Matsumoto; Akira Wada; Mizuki Hino; Takeshi Hashimoto; Akitoyo Hishimoto; Noboru Kitamura; Shuji Iritani; Osamu Shirakawa; Kiyoshi Maeda; Akinori Miyashita; Shin-Ichi Niwa; Hitoshi Takahashi; Akiyoshi Kakita; Ryozo Kuwano; Hiroyuki Nawa
Journal:  Mol Cytogenet       Date:  2015-07-01       Impact factor: 2.009

3.  Absence of substantial copy number differences in a pair of monozygotic twins discordant for features of autism spectrum disorder.

Authors:  Marina Laplana; José Luis Royo; Anton Aluja; Ricard López; Damiàn Heine-Sunyer; Joan Fibla
Journal:  Case Rep Genet       Date:  2014-01-19

4.  Genomic screening of testicular germ cell tumors from monozygotic twins.

Authors:  Sara Martoreli Silveira; Isabela Werneck da Cunha; Fabio Albuquerque Marchi; Ariane Fidelis Busso; Ademar Lopes; Silvia Regina Rogatto
Journal:  Orphanet J Rare Dis       Date:  2014-11-26       Impact factor: 4.123

5.  Failure to Identify Somatic Mutations in Monozygotic Twins Discordant for Schizophrenia by Whole Exome Sequencing.

Authors:  Nan Lyu; Li-Li Guan; Hong Ma; Xi-Jin Wang; Bao-Ming Wu; Fan-Hong Shang; Dan Wang; Hong Wen; Xin Yu
Journal:  Chin Med J (Engl)       Date:  2016-03-20       Impact factor: 2.628

6.  Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia.

Authors:  C A Castellani; M G Melka; J L Gui; A J Gallo; R L O'Reilly; S M Singh
Journal:  Clin Transl Med       Date:  2017-11-28

7.  Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder.

Authors:  Y-C Chen; G Sudre; W Sharp; F Donovan; S C Chandrasekharappa; N Hansen; L Elnitski; P Shaw
Journal:  Mol Psychiatry       Date:  2017-03-21       Impact factor: 15.992

Review 8.  Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies.

Authors:  Akira Imamura; Yoshiro Morimoto; Shinji Ono; Naohiro Kurotaki; Shinji Kanegae; Naoki Yamamoto; Hirohisa Kinoshita; Takahiro Tsujita; Yuji Okazaki; Hiroki Ozawa
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  8 in total

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