AIM: To examine the relationship between a childhood diagnosis of attention deficit hyperactivity disorder (ADHD) with or without oppositional defiant disorder (ODD)/conduct disorder (CD) and the development of later alcohol/drug use disorder [psychoactive substance use disorder (PSUD)] and nicotine dependence in a large European sample of ADHD probands, their siblings and healthy control subjects. PARTICIPANTS, DESIGN AND SETTING: Subjects (n = 1017) were participants in the Belgian, Dutch and German part of the International Multicenter ADHD Genetics (IMAGE) study. IMAGE families were identified through ADHD probands aged 5-17 years attending out-patient clinics, and control subjects from the same geographic areas. After a follow-up period (mean: 4.4 years) this subsample was re-assessed at a mean age of 16.4 years. MEASUREMENTS: PSUD and nicotine dependence were assessed using the Diagnostic Interview Schedule for Children, Alcohol Use Disorders Identification Test, Drug Abuse Screening Test and Fagerström test for Nicotine Dependence. FINDINGS: The ADHD sample was at higher risk of developing PSUD [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.05-3.00] and nicotine dependence (HR = 8.61, 95% CI = 2.44-30.34) than healthy controls. The rates of these disorders were highest for ADHD youth who also had CD, but could not be accounted for by this comorbidity. We did not find an increased risk of developing PSUD (HR = 1.18, 95% CI = 0.62-2.27) or nicotine dependence (HR = 1.89, 95% CI = 0.46-7.77) among unaffected siblings of ADHD youth. CONCLUSIONS: A childhood diagnosis of attention deficit hyperactivity disorder is a risk factor for psychoactive substance use disorder and nicotine dependence in adolescence and comorbid conduct disorder, but not oppositional defiant disorder, further increases the risk of developing psychoactive substance use disorder and nicotine dependence.
AIM: To examine the relationship between a childhood diagnosis of attention deficit hyperactivity disorder (ADHD) with or without oppositional defiant disorder (ODD)/conduct disorder (CD) and the development of later alcohol/drug use disorder [psychoactive substance use disorder (PSUD)] and nicotine dependence in a large European sample of ADHD probands, their siblings and healthy control subjects. PARTICIPANTS, DESIGN AND SETTING: Subjects (n = 1017) were participants in the Belgian, Dutch and German part of the International Multicenter ADHD Genetics (IMAGE) study. IMAGE families were identified through ADHD probands aged 5-17 years attending out-patient clinics, and control subjects from the same geographic areas. After a follow-up period (mean: 4.4 years) this subsample was re-assessed at a mean age of 16.4 years. MEASUREMENTS: PSUD and nicotine dependence were assessed using the Diagnostic Interview Schedule for Children, Alcohol Use Disorders Identification Test, Drug Abuse Screening Test and Fagerström test for Nicotine Dependence. FINDINGS: The ADHD sample was at higher risk of developing PSUD [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.05-3.00] and nicotine dependence (HR = 8.61, 95% CI = 2.44-30.34) than healthy controls. The rates of these disorders were highest for ADHD youth who also had CD, but could not be accounted for by this comorbidity. We did not find an increased risk of developing PSUD (HR = 1.18, 95% CI = 0.62-2.27) or nicotine dependence (HR = 1.89, 95% CI = 0.46-7.77) among unaffected siblings of ADHD youth. CONCLUSIONS: A childhood diagnosis of attention deficit hyperactivity disorder is a risk factor for psychoactive substance use disorder and nicotine dependence in adolescence and comorbid conduct disorder, but not oppositional defiant disorder, further increases the risk of developing psychoactive substance use disorder and nicotine dependence.
Authors: Kristina A Neely; Amanda P Chennavasin; Arie Yoder; Genevieve K R Williams; Eric Loken; Cynthia L Huang-Pollock Journal: Exp Brain Res Date: 2016-07-09 Impact factor: 1.972
Authors: Brooke S G Molina; Andrea L Howard; James M Swanson; Annamarie Stehli; John T Mitchell; Traci M Kennedy; Jeffery N Epstein; L Eugene Arnold; Lily Hechtman; Benedetto Vitiello; Betsy Hoza Journal: J Child Psychol Psychiatry Date: 2018-01-08 Impact factor: 8.982
Authors: Irene J Elkins; Gretchen R B Saunders; Stephen M Malone; Margaret A Keyes; Matt McGue; William G Iacono Journal: Drug Alcohol Depend Date: 2017-12-27 Impact factor: 4.492
Authors: Kevin P Conway; Victoria R Green; Karin A Kasza; Marushka L Silveira; Nicolette Borek; Heather L Kimmel; James D Sargent; Cassandra A Stanton; Elizabeth Lambert; Nahla Hilmi; Chad J Reissig; Kia J Jackson; Susanne E Tanski; David Maklan; Andrew J Hyland; Wilson M Compton Journal: Addict Behav Date: 2017-08-18 Impact factor: 3.913
Authors: Annabeth P Groenman; Corina U Greven; Marjolein M J van Donkelaar; Arnt Schellekens; Kimm J E van Hulzen; Nanda Rommelse; Catharina A Hartman; Pieter J Hoekstra; Marjolein Luman; Barbara Franke; Stephen V Faraone; Jaap Oosterlaan; Jan K Buitelaar Journal: Addict Biol Date: 2015-03-06 Impact factor: 4.280
Authors: William B Brinkman; Jeffery N Epstein; Peggy Auinger; Leanne Tamm; Tanya E Froehlich Journal: Drug Alcohol Depend Date: 2014-12-02 Impact factor: 4.492
Authors: Hanneke van Ewijk; Annabeth P Groenman; Marcel P Zwiers; Dirk J Heslenfeld; Stephen V Faraone; Catharina A Hartman; Marjolein Luman; Corina U Greven; Pieter J Hoekstra; Barbara Franke; Jan Buitelaar; Jaap Oosterlaan Journal: Hum Brain Mapp Date: 2014-12-06 Impact factor: 5.038