BACKGROUND: Our aim of this study was to evaluate the possible association between homocysteine levels and Buerger's disease in a case-control study. METHODS: 25 patients with Buerger's disease based on Shionoya's clinical criteria, and 25 heavy smokers along with 25 healthy non-smokers (control) were recruited for this study. All groups were matched for age. Plasma homocysteine levels were measured in each patient and then compared between the three groups. RESULTS: The mean plasma concentration of homocysteine was 16.88 mmol/L in the Buerger sufferers; as for the smoker (group 2) and control (group 3) groups, the level was as low as 13.89 and 13.56 mmol/L, respectively. CONCLUSIONS: Patients with thromboangiitis obliterans, especially those with a progressive course, benefit from the hyperhomocysteinemia screening test.
BACKGROUND: Our aim of this study was to evaluate the possible association between homocysteine levels and Buerger's disease in a case-control study. METHODS: 25 patients with Buerger's disease based on Shionoya's clinical criteria, and 25 heavy smokers along with 25 healthy non-smokers (control) were recruited for this study. All groups were matched for age. Plasma homocysteine levels were measured in each patient and then compared between the three groups. RESULTS: The mean plasma concentration of homocysteine was 16.88 mmol/L in the Buerger sufferers; as for the smoker (group 2) and control (group 3) groups, the level was as low as 13.89 and 13.56 mmol/L, respectively. CONCLUSIONS:Patients with thromboangiitis obliterans, especially those with a progressive course, benefit from the hyperhomocysteinemia screening test.
Authors: Ali Akbar Beigi; Mohammad Ali Hoghoughi; Afrooz Eshaghian; Akbar Hassan Zade; Hassan Masoudpour Journal: J Res Med Sci Date: 2014-11 Impact factor: 1.852