Literature DB >> 23505087

Vasculitis reminds us that 'Ockham's razor' may still apply in the elderly.

Hillary R Mount1.   

Abstract

A 76-year-old woman with a history of stage IV chronic kidney disease and hypertension was admitted to the hospital for progressive weakness and acute on chronic kidney injury. She was found to have anaemia requiring transfusion. On the evening of admission, she had worsening respiratory status with subsequent diagnosis of a non-ST-elevation myocardial infarction, pulmonary oedema on chest x-ray presumed to be a result of heart failure, and a possible transfusion reaction. A kidney biopsy performed as part of her ongoing nephrology evaluation revealed granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis). Subsequent bronchoalveolar lavage confirmed diffuse alveolar haemorrhage as the explanation for her anaemia and respiratory decline. She underwent immunosuppressive therapies and initiated dialysis, but subsequently chose hospice care and died 2 months after her diagnosis.

Entities:  

Mesh:

Year:  2013        PMID: 23505087      PMCID: PMC3618817          DOI: 10.1136/bcr-2013-008685

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

Review 1.  Diagnosis and management of ANCA associated vasculitis.

Authors:  Annelies Berden; Arda Göçeroglu; David Jayne; Raashid Luqmani; Niels Rasmussen; Jan Anthonie Bruijn; Ingeborg Bajema
Journal:  BMJ       Date:  2012-01-16

Review 2.  The CARI guidelines. ANCA serology in the diagnosis and management of ANCA-associated renal vasculitis.

Authors:  Grant Luxton; Robyn Langham
Journal:  Nephrology (Carlton)       Date:  2008-07       Impact factor: 2.506

3.  The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis.

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Journal:  Ann Intern Med       Date:  1995-12-15       Impact factor: 25.391

Review 4.  Wegener's granulomatosis.

Authors:  G F Duna; C Galperin; G S Hoffman
Journal:  Rheum Dis Clin North Am       Date:  1995-11       Impact factor: 2.670

5.  The epidemiology of Wegener's granulomatosis. Estimates of the five-year period prevalence, annual mortality, and geographic disease distribution from population-based data sources.

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Journal:  Arthritis Rheum       Date:  1996-01

Review 6.  Small-vessel vasculitis.

Authors:  J C Jennette; R J Falk
Journal:  N Engl J Med       Date:  1997-11-20       Impact factor: 91.245

Review 7.  International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)

Authors:  J Savige; D Gillis; E Benson; D Davies; V Esnault; R J Falk; E C Hagen; D Jayne; J C Jennette; B Paspaliaris; W Pollock; C Pusey; C O Savage; R Silvestrini; F van der Woude; J Wieslander; A Wiik
Journal:  Am J Clin Pathol       Date:  1999-04       Impact factor: 2.493

8.  Prevalence and incidence of Wegener's granulomatosis in the UK general practice research database.

Authors:  Richard A Watts; Abdullah Al-Taiar; David G I Scott; Alex J Macgregor
Journal:  Arthritis Rheum       Date:  2009-10-15
  8 in total

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