Anja Betgen1, Rick L M Haas, Jan-Jakob Sonke. 1. Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Abstract
OBJECTIVE: The objective of this study is to quantify volume changes in the gross target volume (GTV) during preoperative radiotherapy for extremity soft tissue sarcomas (ESTS). METHODS: Twenty-seven patients with ESTS, treated with preoperative radiotherapy, were included in this study. Weekly cone-beam CT scans acquired for setup correction were used for GTV delineation in order to quantify volume changes over the course of treatment. Age, anatomical location, tumour type and tumour volume were evaluated as predictive factors for volume changes. Finally, the optimal time point for adaptive intervention was quantified. RESULTS: A GTV increase to a maximum of 28 % occurred in five patients. Thirteen patients showed no change and nine patients (all diagnosed with myxoid liposarcoma (MLS)) showed a GTV decrease to a maximum of 57 % of the GTV volume at start of treatment. In the multivariate analysis, only the relative volume change for tumour type was significant (p = 0.001). The optimal time point for adaptive intervention in non-MLS patients was the first week and for MLS patients the third week. CONCLUSIONS: Volume changes were quantified during preoperative RT of ESTS. Volume decrease was observed only in MLS patients. Individualised treatment resulting in plan adaptations could result in a clinically useful volume reduction for MLS patients.
OBJECTIVE: The objective of this study is to quantify volume changes in the gross target volume (GTV) during preoperative radiotherapy for extremity soft tissue sarcomas (ESTS). METHODS: Twenty-seven patients with ESTS, treated with preoperative radiotherapy, were included in this study. Weekly cone-beam CT scans acquired for setup correction were used for GTV delineation in order to quantify volume changes over the course of treatment. Age, anatomical location, tumour type and tumour volume were evaluated as predictive factors for volume changes. Finally, the optimal time point for adaptive intervention was quantified. RESULTS: A GTV increase to a maximum of 28 % occurred in five patients. Thirteen patients showed no change and nine patients (all diagnosed with myxoid liposarcoma (MLS)) showed a GTV decrease to a maximum of 57 % of the GTV volume at start of treatment. In the multivariate analysis, only the relative volume change for tumour type was significant (p = 0.001). The optimal time point for adaptive intervention in non-MLSpatients was the first week and for MLSpatients the third week. CONCLUSIONS: Volume changes were quantified during preoperative RT of ESTS. Volume decrease was observed only in MLSpatients. Individualised treatment resulting in plan adaptations could result in a clinically useful volume reduction for MLSpatients.
Authors: David A Jaffray; Jeffrey H Siewerdsen; John W Wong; Alvaro A Martinez Journal: Int J Radiat Oncol Biol Phys Date: 2002-08-01 Impact factor: 7.038
Authors: Brian O'Sullivan; Aileen M Davis; Robert Turcotte; Robert Bell; Charles Catton; Pierre Chabot; Jay Wunder; Rita Kandel; Karen Goddard; Anna Sadura; Joseph Pater; Benny Zee Journal: Lancet Date: 2002-06-29 Impact factor: 79.321
Authors: O S Nielsen; B Cummings; B O'Sullivan; C Catton; R S Bell; V L Fornasier Journal: Int J Radiat Oncol Biol Phys Date: 1991-11 Impact factor: 7.038
Authors: Ronald S A de Vreeze; Daphne de Jong; Rick L Haas; Fiona Stewart; Frits van Coevorden Journal: Int J Radiat Oncol Biol Phys Date: 2008-04-28 Impact factor: 7.038
Authors: A N Wilson; A Davis; R S Bell; B O'Sullivan; C Catton; F Madadi; R Kandel; V L Fornasier Journal: Eur J Cancer Date: 1994 Impact factor: 9.162
Authors: Colleen I Dickie; Amy L Parent; Anthony M Griffin; Sharon Fung; Peter W M Chung; Charles N Catton; Peter C Ferguson; Jay S Wunder; Robert S Bell; Michael B Sharpe; Brian O'Sullivan Journal: Int J Radiat Oncol Biol Phys Date: 2009-04-11 Impact factor: 7.038
Authors: Rick L M Haas; Aisha B Miah; Cécile LePechoux; Thomas F DeLaney; Elizabeth H Baldini; Kaled Alektiar; Brian O'Sullivan Journal: Radiother Oncol Date: 2015-12-21 Impact factor: 6.280
Authors: Ramiz Abu-Hijlih; Sara Mheid; Fawzi Abuhijla; Wafa Asha; Issa Mohamad; Abdullah Alrashdan; Samer Alheet; Haitham Kana'an; Mohammad Abd Al-Raheem; Abdelatif Almousa Journal: Rep Pract Oncol Radiother Date: 2019-03-18
Authors: Siyer Roohani; Felix Ehret; Marta Kobus; Anne Flörcken; Sven Märdian; Jana Käthe Striefler; Daniel Rau; Robert Öllinger; Armin Jarosch; Volker Budach; David Kaul Journal: Radiat Oncol Date: 2022-09-14 Impact factor: 4.309
Authors: Linus Hyunsuk Lee; Sarah Tepper; Grant Owen; Dian Wang; Nicolas Lopez-Hisijos; Matthew W Colman; Steven Gitelis; Alan T Blank Journal: Radiat Oncol J Date: 2022-09-06