Literature DB >> 23503514

Immunology of aging and cancer development.

Tamas Fulop1, Anis Larbi, Rami Kotb, Graham Pawelec.   

Abstract

The incidence and prevalence of most cancers increase with age. The immune system is a unique mechanism of defense against pathogens and possibly cancers, however there is a body of evidence that the immune system of the aged is eroded, a phenomenon termed immunosenescence. Each arm of the immune system, innate and adaptive, is altered with aging, contributing to increased tumorigenesis. Related to immunosenescence, a low-grade inflammation also develops with aging contributing also to increase carcinogenesis. Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions in the elderly.
Copyright © 2013 S. Karger AG, Basel.

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Year:  2013        PMID： 23503514     DOI： 10.1159/000343599

Source DB:  PubMed          Journal:  Interdiscip Top Gerontol        ISSN： 0074-1132


  8 in total

1.  Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes.

Authors:  Scott M J Cornwall; Matthew Wikstrom; Arthur W Musk; John Alvarez; Anna K Nowak; Delia J Nelson
Journal:  Oncoimmunology       Date:  2015-08-31       Impact factor: 8.110

Review 2.  The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.

Authors:  Primož Rožman
Journal:  Geroscience       Date:  2018-06-14       Impact factor: 7.713

3.  Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to Mycobacterium tuberculosis Infection.

Authors:  William P Lafuse; Murugesan V S Rajaram; Qian Wu; Juan I Moliva; Jordi B Torrelles; Joanne Turner; Larry S Schlesinger
Journal:  J Immunol       Date:  2019-09-11       Impact factor: 5.422

4.  CD4/CD8 Ratio and Cancer Risk Among Adults With HIV.

Authors:  Jessica L Castilho; Aihua Bian; Cathy A Jenkins; Bryan E Shepherd; Keith Sigel; M John Gill; Mari M Kitahata; Michael J Silverberg; Angel M Mayor; Sally B Coburn; Dorothy Wiley; Chad J Achenbach; Vincent C Marconi; Ronald J Bosch; Michael A Horberg; Charles S Rabkin; Sonia Napravnik; Richard M Novak; W Christopher Mathews; Jennifer E Thorne; Jing Sun; Keri N Althoff; Richard D Moore; Timothy R Sterling; Staci L Sudenga
Journal:  J Natl Cancer Inst       Date:  2022-06-13       Impact factor: 11.816

Review 5.  Regulation of tumor growth and metastasis: the role of tumor microenvironment.

Authors:  Hadi A Goubran; Rami R Kotb; Julie Stakiw; Mohamed E Emara; Thierry Burnouf
Journal:  Cancer Growth Metastasis       Date:  2014-06-02

Review 6.  T Cell Subpopulations in Healthy Elderly and Lung Cancer Patients: Insights from Cuban Studies.

Authors:  Danay Saavedra; Beatriz Garcia; Agustin Lage
Journal:  Front Immunol       Date:  2017-02-14       Impact factor: 7.561

Review 7.  The interplay between immunosenescence and age-related diseases.

Authors:  Florencia Barbé-Tuana; Giselle Funchal; Carine Raquel Richter Schmitz; Rafael Moura Maurmann; Moisés E Bauer
Journal:  Semin Immunopathol       Date:  2020-08-03       Impact factor: 9.623

8.  Immune Checkpoints Inhibitors and Chemotherapy as First-Line Treatment for Metastatic Urothelial Carcinoma: A Network Meta-Analysis of Randomized Phase III Clinical Trials.

Authors:  Hsiao-Ling Chen; Vinson Wai-Shun Chan; Yu-Kang Tu; Erica On-Ting Chan; Hsiu-Mei Chang; Yung-Shun Juan; Jeremy Yuen-Chun Teoh; Hsiang Ying Lee
Journal:  Cancers (Basel)       Date:  2021-03-23       Impact factor: 6.639
  8 in total

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