Literature DB >> 23502676

Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae.

Görkem Garipler1, Cory D Dunn.   

Abstract

While searching for mutations that alleviate detrimental effects of mitochondrial DNA (mtDNA) damage, we found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss. Furthermore, elevating vacuolar pH increases proliferation after mtDNA deletion and reverses the protein import defect of mitochondria lacking DNA.

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Year:  2013        PMID： 23502676      PMCID： PMC3632477          DOI： 10.1534/genetics.113.149708

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  47 in total

1.  INDUCTION OF PETITE MUTATION AND INHIBITION OF SYNTHESIS OF RESPIRATORY ENZYMES IN VARIOUS YEASTS.

Authors:  C J BULDER
Journal:  Antonie Van Leeuwenhoek       Date:  1964       Impact factor: 2.271

2.  New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

Authors:  N Ogawa; J DeRisi; P O Brown
Journal:  Mol Biol Cell       Date:  2000-12       Impact factor: 4.138

3.  Requirement of a membrane potential for the posttranslational transfer of proteins into mitochondria.

Authors:  M Schleyer; B Schmidt; W Neupert
Journal:  Eur J Biochem       Date:  1982-06-15

4.  Kinetic properties of F1-ATPase influence the ability of yeasts to grow in anoxia or absence of mtDNA.

Authors:  G Desmond Clark-Walker
Journal:  Mitochondrion       Date:  2003-03       Impact factor: 4.160

5.  Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptides.

Authors:  G A Reid; G Schatz
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157

6.  Suppression of a defect in mitochondrial protein import identifies cytosolic proteins required for viability of yeast cells lacking mitochondrial DNA.

Authors:  Cory D Dunn; Robert E Jensen
Journal:  Genetics       Date:  2003-09       Impact factor: 4.562

7.  Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae.

Authors:  K H Berger; M P Yaffe
Journal:  Mol Cell Biol       Date:  1998-07       Impact factor: 4.272

8.  Mutations in the mitochondrial ATP synthase gamma subunit suppress a slow-growth phenotype of yme1 yeast lacking mitochondrial DNA.

Authors:  E R Weber; R S Rooks; K S Shafer; J W Chase; P E Thorsness
Journal:  Genetics       Date:  1995-06       Impact factor: 4.562

9.  Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape.

Authors:  H Sesaki; R E Jensen
Journal:  J Cell Biol       Date:  1999-11-15       Impact factor: 10.539

10.  Characterization of yeast V-ATPase mutants lacking Vph1p or Stv1p and the effect on endocytosis.

Authors:  Natalie Perzov; Vered Padler-Karavani; Hannah Nelson; Nathan Nelson
Journal:  J Exp Biol       Date:  2002-05       Impact factor: 3.312
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  11 in total

1.  Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Authors:  Nicola Baker; Graham Hamilton; Jonathan M Wilkes; Sebastian Hutchinson; Michael P Barrett; David Horn
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205

Review 2.  The retrograde response: a conserved compensatory reaction to damage from within and from without.

Authors:  S Michal Jazwinski
Journal:  Prog Mol Biol Transl Sci       Date:  2014       Impact factor: 3.622

3.  Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.

Authors:  Joanne M Kingsbury; Neelam D Sen; Tatsuya Maeda; Joseph Heitman; Maria E Cardenas
Journal:  Genetics       Date:  2014-02-10       Impact factor: 4.562

4.  Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae.

Authors:  Görkem Garipler; Nebibe Mutlu; Nathan A Lack; Cory D Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205

Review 5.  Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies.

Authors:  Jean-Paul Lasserre; Alain Dautant; Raeka S Aiyar; Roza Kucharczyk; Annie Glatigny; Déborah Tribouillard-Tanvier; Joanna Rytka; Marc Blondel; Natalia Skoczen; Pascal Reynier; Laras Pitayu; Agnès Rötig; Agnès Delahodde; Lars M Steinmetz; Geneviève Dujardin; Vincent Procaccio; Jean-Paul di Rago
Journal:  Dis Model Mech       Date:  2015-06       Impact factor: 5.758

Review 6.  Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension.

Authors:  Mikael Molin; Ayse Banu Demir
Journal:  Int J Cell Biol       Date:  2014-02-03

7.  Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.

Authors:  Emel Akdoğan; Mehmet Tardu; Görkem Garipler; Gülkız Baytek; İ Halil Kavakli; Cory D Dunn
Journal:  PLoS One       Date:  2016-01-11       Impact factor: 3.240

8.  Activation of the pleiotropic drug resistance pathway can promote mitochondrial DNA retention by fusion-defective mitochondria in Saccharomyces cerevisiae.

Authors:  Nebibe Mutlu; Görkem Garipler; Emel Akdoğan; Cory D Dunn
Journal:  G3 (Bethesda)       Date:  2014-05-07       Impact factor: 3.154

9.  Metabolic and environmental conditions determine nuclear genomic instability in budding yeast lacking mitochondrial DNA.

Authors:  Léon Dirick; Walid Bendris; Vincent Loubiere; Thierry Gostan; Elisabeth Gueydon; Etienne Schwob
Journal:  G3 (Bethesda)       Date:  2014-03-20       Impact factor: 3.154

10.  Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions.

Authors:  Marco Tigano; Roberta Ruotolo; Cristina Dallabona; Flavia Fontanesi; Antoni Barrientos; Claudia Donnini; Simone Ottonello
Journal:  Nucleic Acids Res       Date:  2015-08-03       Impact factor: 16.971
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