Literature DB >> 2350187

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C.

K Sato1, E Niki, H Shimasaki.   

Abstract

The oxidation of human low density lipoprotein (LDL) initiated by free radical initiator and its inhibition by vitamin E and water-soluble antioxidants have been studied. It was found that the kinetic chain length was considerably larger than 1, suggesting that LDL was oxidized by a free radical chain mechanism. Vitamin E acted as a lipophilic chain-breaking antioxidant. Water-soluble chain-breaking antioxidants such as ascorbic acid and uric acid suppressed the oxidation of LDL initiated by aqueous radicals but they could not scavenge lipophilic radicals within LDL to break the chain propagation. Ascorbic acid acted as a synergistic antioxidant in conjunction with vitamin E.

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Year:  1990        PMID： 2350187     DOI： 10.1016/0003-9861(90)90508-v

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  27 in total

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Review 4.  Mechanisms of free radical oxidation of unsaturated lipids.

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8.  Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway.

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Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

9.  Long-term feeding effects of heated and fried oils on hepatic antioxidant enzymes, absorption and excretion of fat in rats.

Authors:  S Purushothama; H D Ramachandran; K Narasimhamurthy; P L Raina
Journal:  Mol Cell Biochem       Date:  2003-05       Impact factor: 3.396

10.  Antioxidant capacities of ascorbic acid, uric acid, alpha-tocopherol, and bilirubin can be measured in the presence of another antioxidant, serum albumin.

Authors:  Hiroshi Ihara; Naotaka Hashizume; Toshio Hasegawa; Mitsutaka Yoshida
Journal:  J Clin Lab Anal       Date:  2004       Impact factor: 2.352
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