Literature DB >> 23500386

Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng.

Qinge Ma1, Jin Tian, Jianbo Yang, Aiguo Wang, Tengfei Ji, Yangai Wang, Yalun Su.   

Abstract

Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 μM) had moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC50 values of 1.773, 1.875 and 2.286 μM, respectively.
Copyright © 2013 Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23500386     DOI： 10.1016/j.fitote.2013.03.003

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  4 in total

1.  Koenimbin, a natural dietary compound of Murraya koenigii (L) Spreng: inhibition of MCF7 breast cancer cells and targeting of derived MCF7 breast cancer stem cells (CD44(+)/CD24(-/low)): an in vitro study.

Authors:  Fatemeh Ahmadipour; Mohamed Ibrahim Noordin; Syam Mohan; Aditya Arya; Mohammadjavad Paydar; Chung Yeng Looi; Yeap Swee Keong; Ebrahimi Nigjeh Siyamak; Somayeh Fani; Maryam Firoozi; Chung Lip Yong; Mohamed Aspollah Sukari; Behnam Kamalidehghan
Journal:  Drug Des Devel Ther       Date:  2015-02-24       Impact factor: 4.162

2.  The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism.

Authors:  Nushrat Sharmin Ani; Sudip Chakraborty; Md Moniruzzaman
Journal:  Adv Pharmacol Sci       Date:  2016-10-12

Review 3.  Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds.

Authors:  Rengasamy Balakrishnan; Dhanraj Vijayraja; Song-Hee Jo; Palanivel Ganesan; In Su-Kim; Dong-Kug Choi
Journal:  Antioxidants (Basel)       Date:  2020-01-24

4.  Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Authors:  Jing-Hua Yang; Xin-Yi Wang; Yi-Ping Zhou; Rong Lu; Chin-Ho Chen; Meng-Han Zhang; Yung-Yi Cheng; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yun-Song Wang
Journal:  Molecules       Date:  2019-12-26       Impact factor: 4.411
  4 in total

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