| Literature DB >> 23499889 |
Yan Jin1, Hengjun Gao, Hao Chen, Jian Wang, Min Chen, Guohua Li, Liwei Wang, Jianren Gu, Hong Tu.
Abstract
Increasing evidence suggests that a link exists between hepatitis B virus (HBV) serum markers and pancreatic cancer (PC). In this study, HBsAg and HBcAg were expressed in 21.0% (34/162) of PC and 29.0% (47/162) of non-tumor pancreatic tissues, and they were significantly associated with chronic pancreatitis (P=0.000). The HBV S, C and X genes were identified in 20% (6/30) of PC and 26.9% (7/26) of non-tumor tissues by PCR. A serological survey revealed that the prevalence of HBV DNA and anti-HBc was significantly increased in PC patients compared with healthy controls. Our data suggest that HBV infection in the pancreas may play an etiologic role in PC.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23499889 DOI： 10.1016/j.canlet.2013.03.001
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679