Literature DB >> 23499447

Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.

Marina E Emborg1, Yan Liu, Jiajie Xi, Xiaoqing Zhang, Yingnan Yin, Jianfeng Lu, Valerie Joers, Christine Swanson, James E Holden, Su-Chun Zhang.   

Abstract

The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.
Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23499447      PMCID： PMC3633566          DOI： 10.1016/j.celrep.2013.02.016

Source DB:  PubMed          Journal:  Cell Rep            Impact factor:   9.423


  29 in total

1.  Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.

Authors:  Matthew T Pankratz; Xue-Jun Li; Timothy M Lavaute; Elizabeth A Lyons; Xin Chen; Su-Chun Zhang
Journal:  Stem Cells       Date:  2007-03-01       Impact factor: 6.277

2.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease.

Authors:  C R Freed; P E Greene; R E Breeze; W Y Tsai; W DuMouchel; R Kao; S Dillon; H Winfield; S Culver; J Q Trojanowski; D Eidelberg; S Fahn
Journal:  N Engl J Med       Date:  2001-03-08       Impact factor: 91.245

3.  Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.

Authors:  Yiping Yan; Dali Yang; Ewa D Zarnowska; Zhongwei Du; Brian Werbel; Chuck Valliere; Robert A Pearce; James A Thomson; Su-Chun Zhang
Journal:  Stem Cells       Date:  2005 Jun-Jul       Impact factor: 6.277

4.  Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.

Authors:  Ivar Mendez; Rosario Sanchez-Pernaute; Oliver Cooper; Angel Viñuela; Daniela Ferrari; Lars Björklund; Alain Dagher; Ole Isacson
Journal:  Brain       Date:  2005-05-04       Impact factor: 13.501

5.  Isolation of a primate embryonic stem cell line.

Authors:  J A Thomson; J Kalishman; T G Golos; M Durning; C P Harris; R A Becker; J P Hearn
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

6.  Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats.

Authors:  Dali Yang; Zhi-Jian Zhang; Michael Oldenburg; Melvin Ayala; Su-Chun Zhang
Journal:  Stem Cells       Date:  2007-10-18       Impact factor: 6.277

7.  Derivation of midbrain dopamine neurons from human embryonic stem cells.

Authors:  Anselme L Perrier; Viviane Tabar; Tiziano Barberi; Maria E Rubio; Juan Bruses; Norbert Topf; Neil L Harrison; Lorenz Studer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-13       Impact factor: 11.205

8.  Intracerebral transplantation of differentiated human embryonic stem cells to hemiparkinsonian monkeys.

Authors:  Marina E Emborg; Zhijian Zhang; Valerie Joers; Kevin Brunner; Viktorya Bondarenko; Sachiko Ohshima; Su-Chun Zhang
Journal:  Cell Transplant       Date:  2013       Impact factor: 4.064

9.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

10.  Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner.

Authors:  Xiaofeng Xia; Yingsha Zhang; Caroline R Zieth; Su-Chun Zhang
Journal:  Stem Cells Dev       Date:  2007-02       Impact factor: 3.272
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  65 in total

Review 1.  Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies.

Authors:  Xixi Du; Jack M Parent
Journal:  Curr Neurol Neurosci Rep       Date:  2015-10       Impact factor: 5.081

Review 2.  Preclinical studies for induced pluripotent stem cell-based therapeutics.

Authors:  John Harding; Oleg Mirochnitchenko
Journal:  J Biol Chem       Date:  2013-12-20       Impact factor: 5.157

3.  Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons.

Authors:  Scott C Vermilyea; Jianfeng Lu; Miles Olsen; Scott Guthrie; Yunlong Tao; Eva M Fekete; Marissa K Riedel; Kevin Brunner; Carissa Boettcher; Viktorya Bondarenko; Ethan Brodsky; Walter F Block; Andrew Alexander; Su-Chun Zhang; Marina E Emborg
Journal:  Cell Transplant       Date:  2016-09-14       Impact factor: 4.064

4.  Epigenetic changes in the developing brain: Effects on behavior.

Authors:  Eric B Keverne; Donald W Pfaff; Inna Tabansky
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-02       Impact factor: 11.205

Review 5.  Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells.

Authors:  Jenne Tran; Helena Anastacio; Cedric Bardy
Journal:  NPJ Parkinsons Dis       Date:  2020-04-24

6.  Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

Authors:  So Gun Hong; Ravi Chandra Yada; Kyujoo Choi; Arnaud Carpentier; T Jake Liang; Randall K Merling; Colin L Sweeney; Harry L Malech; Moonjung Jung; Marcus A F Corat; Aisha A AlJanahi; Yongshun Lin; Huimin Liu; Ilker Tunc; Xujing Wang; Maryknoll Palisoc; Stefania Pittaluga; Manfred Boehm; Thomas Winkler; Jizhong Zou; Cynthia E Dunbar
Journal:  Mol Ther       Date:  2017-01-04       Impact factor: 11.454

Review 7.  Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach.

Authors:  In K Cho; Silun Wang; Hui Mao; Anthony Ws Chan
Journal:  Am J Nucl Med Mol Imaging       Date:  2016-09-22

8.  Rhesus Macaque iPSC Generation and Maintenance.

Authors:  Ravi Chandra Yada; So Gun Hong; Yongshun Lin; Thomas Winkler; Cynthia E Dunbar
Journal:  Curr Protoc Stem Cell Biol       Date:  2017-05-16

9.  Inhibition of master transcription factors in pluripotent cells induces early stage differentiation.

Authors:  Debojyoti De; Myong-Ho Jeong; Young-Eun Leem; Dmitri I Svergun; David E Wemmer; Jong-Sun Kang; Kyeong Kyu Kim; Sung-Hou Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-16       Impact factor: 11.205

10.  Induced pluripotent stem cell reprogramming by integration-free Sendai virus vectors from peripheral blood of patients with craniometaphyseal dysplasia.

Authors:  I-Ping Chen; Keiichi Fukuda; Noemi Fusaki; Akihiro Iida; Mamoru Hasegawa; Alexander Lichtler; Ernst J Reichenberger
Journal:  Cell Reprogram       Date:  2013-11-12       Impact factor: 1.987
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