BACKGROUND: Since the Diabetes Prevention Project (DPP) demonstrated that lifestyle weight-loss interventions can reduce the incidence of diabetes by 58%, several studies have translated the DPP methods to public health-friendly contexts. Although these studies have demonstrated short-term effects, no study to date has examined the impact of a translated DPP intervention on blood glucose and adiposity beyond 12 months of follow-up. PURPOSE: To examine the impact of a 24-month, community-based diabetes prevention program on fasting blood glucose, insulin, insulin resistance as well as body weight, waist circumference, and BMI in the second year of follow-up. DESIGN: An RCT comparing a 24-month lifestyle weight-loss program (LWL) to an enhanced usual care condition (UCC) in participants with prediabetes (fasting blood glucose=95-125 mg/dL). Data were collected in 2007-2011; analyses were conducted in 2011-2012. SETTING/PARTICIPANTS: 301 participants with prediabetes were randomized; 261 completed the study. The intervention was held in community-based sites. INTERVENTION: The LWL program was led by community health workers and sought to induce 7% weight loss at 6 months that would be maintained over time through decreased caloric intake and increased physical activity. The UCC received two visits with a registered dietitian and a monthly newsletter. MAIN OUTCOME MEASURES: The main measures were fasting blood glucose, insulin, insulin resistance, body weight, waist circumference, and BMI. RESULTS: Intent-to-treat analyses of between-group differences in the average of 18- and 24-month measures of outcomes (controlling for baseline values) revealed that the LWL participants experienced greater decreases in fasting glucose (-4.35 mg/dL); insulin (-3.01 μU/ml); insulin resistance (-0.97); body weight (-4.19 kg); waist circumference (-3.23 cm); and BMI (-1.40), all p-values <0.01. CONCLUSIONS: A diabetes prevention program administered through an existing community-based system and delivered by community health workers is effective at inducing significant long-term reductions in metabolic indicators and adiposity.
RCT Entities:
BACKGROUND: Since the Diabetes Prevention Project (DPP) demonstrated that lifestyle weight-loss interventions can reduce the incidence of diabetes by 58%, several studies have translated the DPP methods to public health-friendly contexts. Although these studies have demonstrated short-term effects, no study to date has examined the impact of a translated DPP intervention on blood glucose and adiposity beyond 12 months of follow-up. PURPOSE: To examine the impact of a 24-month, community-based diabetes prevention program on fasting blood glucose, insulin, insulin resistance as well as body weight, waist circumference, and BMI in the second year of follow-up. DESIGN: An RCT comparing a 24-month lifestyle weight-loss program (LWL) to an enhanced usual care condition (UCC) in participants with prediabetes (fasting blood glucose=95-125 mg/dL). Data were collected in 2007-2011; analyses were conducted in 2011-2012. SETTING/PARTICIPANTS: 301 participants with prediabetes were randomized; 261 completed the study. The intervention was held in community-based sites. INTERVENTION: The LWL program was led by community health workers and sought to induce 7% weight loss at 6 months that would be maintained over time through decreased caloric intake and increased physical activity. The UCC received two visits with a registered dietitian and a monthly newsletter. MAIN OUTCOME MEASURES: The main measures were fasting blood glucose, insulin, insulin resistance, body weight, waist circumference, and BMI. RESULTS: Intent-to-treat analyses of between-group differences in the average of 18- and 24-month measures of outcomes (controlling for baseline values) revealed that the LWL participants experienced greater decreases in fasting glucose (-4.35 mg/dL); insulin (-3.01 μU/ml); insulin resistance (-0.97); body weight (-4.19 kg); waist circumference (-3.23 cm); and BMI (-1.40), all p-values <0.01. CONCLUSIONS: A diabetes prevention program administered through an existing community-based system and delivered by community health workers is effective at inducing significant long-term reductions in metabolic indicators and adiposity.
Authors: A Katsuki; Y Sumida; E C Gabazza; S Murashima; M Furuta; R Araki-Sasaki; Y Hori; Y Yano; Y Adachi Journal: Diabetes Care Date: 2001-02 Impact factor: 19.112
Authors: Caroline S Blackwell; Kara A Foster; Scott Isom; Jeffrey A Katula; Mara Z Vitolins; Erica L Rosenberger; David C Goff Journal: Contemp Clin Trials Date: 2010-10-23 Impact factor: 2.226
Authors: Jeffrey A Katula; Mara Z Vitolins; Erica L Rosenberger; Caroline Blackwell; Mark A Espeland; Michael S Lawlor; W Jack Rejeski; David C Goff Journal: Contemp Clin Trials Date: 2009-09-13 Impact factor: 2.226
Authors: Robert Ross; Miu Lam; Steven N Blair; Timothy S Church; Marshall Godwin; Stephen B Hotz; Ana Johnson; Peter T Katzmarzyk; Lucie Lévesque; Susan MacDonald Journal: Arch Intern Med Date: 2012-02-27
Authors: Marjorie K Mau; Joseph Keawe'aimoku Kaholokula; Margaret R West; Anne Leake; James T Efird; Charles Rose; Donna-Marie Palakiko; Sheryl Yoshimura; Puni B Kekauoha; Henry Gomes Journal: Prog Community Health Partnersh Date: 2010
Authors: Delia Smith West; Zoran Bursac; Carol E Cornell; Holly C Felix; Jennifer K Fausett; Rebecca A Krukowski; Shelly Lensing; Sharhonda J Love; T Elaine Prewitt; Cornelia Beck Journal: Am J Prev Med Date: 2011-10 Impact factor: 5.043
Authors: Thomas A Wadden; Sheri Volger; David B Sarwer; Marion L Vetter; Adam G Tsai; Robert I Berkowitz; Shiriki Kumanyika; Kathryn H Schmitz; Lisa K Diewald; Ronald Barg; Jesse Chittams; Reneé H Moore Journal: N Engl J Med Date: 2011-11-14 Impact factor: 91.245
Authors: Ronald T Ackermann; Emily A Finch; Edward Brizendine; Honghong Zhou; David G Marrero Journal: Am J Prev Med Date: 2008-10 Impact factor: 5.043
Authors: Jeffrey A Katula; Mara Z Vitolins; Erica L Rosenberger; Caroline S Blackwell; Timothy M Morgan; Michael S Lawlor; David C Goff Journal: Diabetes Care Date: 2011-05-18 Impact factor: 19.112
Authors: EunSeok Cha; Kevin H Kim; Guillermo Umpierrez; Colleen R Dawkins; Morenike K Bello; Hannah M Lerner; K M Venkat Narayan; Sandra B Dunbar Journal: Diabetes Educ Date: 2014-06-20 Impact factor: 2.140
Authors: Mara Z Vitolins; Caroline S Blackwell; Jeffrey A Katula; Scott P Isom; L Douglas Case Journal: Diabetes Care Date: 2019-07-11 Impact factor: 19.112
Authors: Mara Z Vitolins; Scott P Isom; Caroline S Blackwell; Donna Kernodle; Joyce M Sydell; Carolyn F Pedley; Jeffrey A Katula; L Douglas Case; David C Goff Journal: Transl Behav Med Date: 2017-06 Impact factor: 3.046
Authors: Jeffrey A Katula; Julienne K Kirk; Carolyn F Pedley; Margaret R Savoca; Valery S Effoe; Ronny A Bell; Alain G Bertoni Journal: Contemp Clin Trials Date: 2016-12-07 Impact factor: 2.226
Authors: L Zheng; J Wu; G Wang; G Persuitte; Y Ma; L Zou; L Zhang; M Zhao; J Wang; Qin Lan; Z Liu; H Fan; J Li Journal: Eur J Clin Nutr Date: 2015-09-02 Impact factor: 4.016