BACKGROUND: An increased risk of metabolic syndrome (MS) has been observed among women with previous gestational diabetes mellitus (pGDM). Increased inflammatory markers such as C-reactive protein (CRP) and interleukin 6 (IL-6) usually accompany. We performed this survey to examine the relationship between pGDM and MS, CRP and IL-6. METHODS: 77 women with pGDM and 67 randomly sampled women free from GDM participated in this study, 2-3 years after index pregnancy. Laboratory and anthropometric measurements were performed. MS was defined according to ATP III criteria. Statistical analyses were conducted using SPSS 18. RESULTS: CRP were different between groups with and without pGDM [2.69 (2.86 mg/dl and 1.56 (1.39) mg/dl, respectively; p < 0.01]. The presence of each MS component by itself was associated with significantly higher CRP Levels, except for fasting blood glucose. In linear regression models, CRP and IL-6 were significantly associated with BMI (β =0. 25, 0.23; p < 0.01), waist circumference (β=0. 27, 0.05; p < 0.01) and HOMA-IR (β=0. 39, 0.39; p < 0.01). After adjustment for age and BMI the occurrence of pGDM in the group with both high CRP and MS was significantly associated with CRP level (OR= 5.11; CI=1.59-16.43; p < 0.01). CONCLUSION: Since CRP and Il-6 were higher in women with both pGDM and MS it appears that the presence of pGDM with MS components have a synergistic effect on the elevation of serum levels of inflammatory markers which can be partly as a result of visceral obesity. Further long-term studies are necessary to confirm the relationship between CRP, IL-6 and MS in women with pGDM.
BACKGROUND: An increased risk of metabolic syndrome (MS) has been observed among women with previous gestational diabetes mellitus (pGDM). Increased inflammatory markers such as C-reactive protein (CRP) and interleukin 6 (IL-6) usually accompany. We performed this survey to examine the relationship between pGDM and MS, CRP and IL-6. METHODS: 77 women with pGDM and 67 randomly sampled women free from GDM participated in this study, 2-3 years after index pregnancy. Laboratory and anthropometric measurements were performed. MS was defined according to ATP III criteria. Statistical analyses were conducted using SPSS 18. RESULTS:CRP were different between groups with and without pGDM [2.69 (2.86 mg/dl and 1.56 (1.39) mg/dl, respectively; p < 0.01]. The presence of each MS component by itself was associated with significantly higher CRP Levels, except for fasting blood glucose. In linear regression models, CRP and IL-6 were significantly associated with BMI (β =0. 25, 0.23; p < 0.01), waist circumference (β=0. 27, 0.05; p < 0.01) and HOMA-IR (β=0. 39, 0.39; p < 0.01). After adjustment for age and BMI the occurrence of pGDM in the group with both high CRP and MS was significantly associated with CRP level (OR= 5.11; CI=1.59-16.43; p < 0.01). CONCLUSION: Since CRP and Il-6 were higher in women with both pGDM and MS it appears that the presence of pGDM with MS components have a synergistic effect on the elevation of serum levels of inflammatory markers which can be partly as a result of visceral obesity. Further long-term studies are necessary to confirm the relationship between CRP, IL-6 and MS in women with pGDM.
Authors: G Di Cianni; C Lencioni; L Volpe; A Ghio; I Cuccuru; G Pellegrini; L Benzi; R Miccoli; S Del Prato Journal: Diabetes Metab Res Rev Date: 2007-02 Impact factor: 4.876
Authors: Aruna D Pradhan; Nancy R Cook; Julie E Buring; JoAnn E Manson; Paul M Ridker Journal: Arterioscler Thromb Vasc Biol Date: 2003-03-06 Impact factor: 8.311
Authors: L Chatzi; E Plana; A Pappas; D Alegkakis; P Karakosta; V Daraki; M Vassilaki; C Tsatsanis; A Kafatos; A Koutis; M Kogevinas Journal: Diabetes Metab Date: 2009-12 Impact factor: 6.041
Authors: A Tranidou; T Dagklis; I Tsakiridis; A Siargkas; A Apostolopoulou; A Mamopoulos; D G Goulis; M Chourdakis Journal: J Endocrinol Invest Date: 2020-11-23 Impact factor: 4.256
Authors: Maleesa M Pathirana; Zohra S Lassi; Anna Ali; Margaret A Arstall; Claire T Roberts; Prabha H Andraweera Journal: Endocrine Date: 2020-09-15 Impact factor: 3.633
Authors: Mingxia Sun; Liying Zhang; Shanying Chen; Xinyu Liu; Xiaofei Shao; Hequn Zou Journal: Int J Environ Res Public Health Date: 2015-07-17 Impact factor: 3.390
Authors: Lauren C Shuffrey; Maristella Lucchini; Santiago Morales; Ayesha Sania; Christine Hockett; Emily Barrett; Kecia N Carroll; Camille C Cioffi; Dana Dabelea; Sean Deoni; Anne L Dunlop; Arielle Deutsch; William P Fifer; Morgan R Firestein; Monique M Hedderson; Melanie Jacobson; Rachel S Kelly; Jean M Kerver; W Alex Mason; Hooman Mirzakhani; Thomas G O'Connor; Leonardo Trasande; Scott Weiss; Rosalind Wright; Yeyi Zhu; Rosa M Crum; Seonjoo Lee; Amy J Elliott; Catherine Monk Journal: BMC Pregnancy Childbirth Date: 2022-10-08 Impact factor: 3.105