PROBLEM: During pregnancy, antibodies are induced that target the paternal human leukocyte antigens of the semi-allogeneic fetus. The level and presence of these antibodies have been reported increased as well as decreased for a variety of pregnancy complications; the clinical relevance and consequences of these antibodies are not very clear. Therefore, the objective of this review is to determine whether the presence of antipaternal antibodies influences pregnancy outcome. METHOD: We performed a systematic search of studies that described the effect of antipaternal antibodies on pregnancy complications. The primary outcome was the risk ratio for HLA class I and class II antibodies on pregnancy complications. Furthermore, we calculated the risk for first- and third-trimester complications. RESULTS: The seventeen studies that were selected for meta-analysis showed high level of statistical and clinical heterogeneity. In the meta-analysis, we found no significant effect of HLA class I or class II antibodies on pregnancy outcome. CONCLUSION: No consistent conclusions can be drawn from the meta-analysis. Discrepancies in the meta-analysis are the result of different screening techniques, varying time points of screening, and use of incorrect control groups. Furthermore, more detailed analyses of the characteristics and specificity of the antibodies involved are essential.
PROBLEM: During pregnancy, antibodies are induced that target the paternal human leukocyte antigens of the semi-allogeneic fetus. The level and presence of these antibodies have been reported increased as well as decreased for a variety of pregnancy complications; the clinical relevance and consequences of these antibodies are not very clear. Therefore, the objective of this review is to determine whether the presence of antipaternal antibodies influences pregnancy outcome. METHOD: We performed a systematic search of studies that described the effect of antipaternal antibodies on pregnancy complications. The primary outcome was the risk ratio for HLA class I and class II antibodies on pregnancy complications. Furthermore, we calculated the risk for first- and third-trimester complications. RESULTS: The seventeen studies that were selected for meta-analysis showed high level of statistical and clinical heterogeneity. In the meta-analysis, we found no significant effect of HLA class I or class II antibodies on pregnancy outcome. CONCLUSION: No consistent conclusions can be drawn from the meta-analysis. Discrepancies in the meta-analysis are the result of different screening techniques, varying time points of screening, and use of incorrect control groups. Furthermore, more detailed analyses of the characteristics and specificity of the antibodies involved are essential.
Authors: V Katsi; I Felekos; C Siristatidis; S Kasioni; A Drakontaidis; G Farmakides; T Makris; C Aggeli; P Nihoyannopoulos; D Tousoulis; I Kallikazaros Journal: Curr Hypertens Rep Date: 2015-08 Impact factor: 5.369
Authors: Kirsten Geneugelijk; Gideon Hönger; Hanneke Wilhelmina Maria van Deutekom; Irene Mathilde Hösli; Stefan Schaub; Eric Spierings Journal: Front Immunol Date: 2016-12-06 Impact factor: 7.561
Authors: Lindert Benedictus; Rutger D Luteijn; Henny Otten; Robert Jan Lebbink; Peter J S van Kooten; Emmanuel J H J Wiertz; Victor P M G Rutten; Ad P Koets Journal: Sci Rep Date: 2015-08-03 Impact factor: 4.379
Authors: Lorenz Küssel; Harald Herkner; Markus Wahrmann; Farsad Eskandary; Konstantin Doberer; Julia Binder; Petra Pateisky; Harald Zeisler; Georg A Böhmig; Gregor Bond Journal: Sci Rep Date: 2017-10-19 Impact factor: 4.379