Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vinculin, cell mechanics and tumour cell invasion.

Literature DB >> 23494917

Vinculin, cell mechanics and tumour cell invasion.

Wolfgang H Goldmann¹, Vera Auernheimer, Ingo Thievessen, Ben Fabry.

Abstract

The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.

Entities: Disease Gene

Mesh：

Substances：
Actins
Vinculin

Year: 2013 PMID： 23494917 DOI： 10.1002/cbin.10064

Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612

Keyword Cloud
Cited

34 in total

1. Cortical Actin Dynamics in Endothelial Permeability.

Authors: Patrick Belvitch; Yu Maw Htwe; Mary E Brown; Steven Dudek
Journal: Curr Top Membr Date: 2018-10-15 Impact factor: 3.049

2. Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses.

Authors: Anna A Birukova; Alok S Shah; Yufeng Tian; Nurgul Moldobaeva; Konstantin G Birukov
Journal: Cell Signal Date: 2016-02-24 Impact factor: 4.315

3. Substrate stiffness regulated migration and invasion ability of adenoid cystic carcinoma cells via RhoA/ROCK pathway.

Authors: Dan Zhao; Qianshun Li; Mengting Liu; Wenjuan Ma; Tengfei Zhou; Changyue Xue; Xiaoxiao Cai
Journal: Cell Prolif Date: 2018-02-08 Impact factor: 6.831

4. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.

Authors: Matthew G Rubashkin; Luke Cassereau; Russell Bainer; Christopher C DuFort; Yoshihiro Yui; Guanqing Ou; Matthew J Paszek; Michael W Davidson; Yunn-Yi Chen; Valerie M Weaver
Journal: Cancer Res Date: 2014-09-01 Impact factor: 12.701

Vinculin, cell mechanics and tumour cell invasion.

1. Cortical Actin Dynamics in Endothelial Permeability.

2. Dual role of vinculin in barrier-disruptive and barrier-enhancing endothelial cell responses.

3. Substrate stiffness regulated migration and invasion ability of adenoid cystic carcinoma cells via RhoA/ROCK pathway.

4. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.

5. Molecular Simulations Suggest a Force-Dependent Mechanism of Vinculin Activation.

Review 6. The Multifaceted Role of HSF1 in Tumorigenesis.

7. Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia.

Review 8. Mechanosensing via cell-matrix adhesions in 3D microenvironments.

9. Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.

10. Coordination between Intra- and Extracellular Forces Regulates Focal Adhesion Dynamics.