Literature DB >> 234945

Dihydrofolate reductases from the wild type and aminopterin-resistant mutants of Diplococcus pneumoniae.

M C Trombe, A M Sicard.   

Abstract

Dihydrofolate reductase from the wild type and aminopterin-resistant mutants of Diplococcus pneumoniae has been compared. Specific activity, optimum pH, Km, thermal stability, and inhibition by aminopterin are identical for both strains. Aminopterin resistance for such mutants is, therefore, not due to an alteration of the dihydrofolate reductase.

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Year:  1975        PMID： 234945      PMCID： PMC246001          DOI： 10.1128/jb.121.3.766-770.1975

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  14 in total

1.  DIHYDROFOLATE REDUCTASE IN GENOTYPICALLY DISTINGUISHABLE AMETHOPTERIN-RESISTANT DIPLOCOCCUS PNEUMONIAE.

Authors:  F M SIROTNAK; G J DONATI; D J HUTCHISON
Journal:  J Biol Chem       Date:  1964-08       Impact factor: 5.157

2.  GENETIC MODIFICATION OF THE STRUCTURE AND AMOUNT OF DIHYDROFOLATE REDUCTASE IN AMETHOPTERIN-RESISTANT DIPLOCOCCUS PNEUMONIAE.

Authors:  F M SIROTNAK; G J DONATI; D J HUTCHISON
Journal:  J Biol Chem       Date:  1964-12       Impact factor: 5.157

3.  Enzyme inhibition in relation to chemotherapy.

Authors:  W W ACKERMANN; V R POTTER
Journal:  Proc Soc Exp Biol Med       Date:  1949-10

4.  Evidence for a genetic alteration of dihydrofolate reductase associated with amethopterin resistance in Diplococcus pneumoniae.

Authors:  F M Sirotnak; G J Donati; D J Hutchison
Journal:  Biochem Biophys Res Commun       Date:  1964       Impact factor: 3.575

5.  Genetic recombination in DNA-induced transformation of Pneumococcus. II. Mapping the amiA region.

Authors:  A M Sicard; H Ephrussi-Taylor
Journal:  Genetics       Date:  1965-12       Impact factor: 4.562

6.  Genetically alterable transport of amethopterin in Diplococcus pneumoniae. II. Impairment of the system associated with various mutant genotypes.

Authors:  F M Sirotnak; M G Sargent; D J Hutchison
Journal:  J Bacteriol       Date:  1967-01       Impact factor: 3.490

7.  Chromatographic repair of storage-inactivated dihydrofolate reductase from Diplococcus pneumoniae.

Authors:  R M Sirotnak; D J Hutchison
Journal:  Arch Biochem Biophys       Date:  1967-08       Impact factor: 4.013

8.  Dihydrofolate reductase and aminopterin resistance in Pneumococcus.

Authors:  S H Benedict; T C Gray
Journal:  Mol Gen Genet       Date:  1973-03-27

9.  [Phenotypic and genetic analysis of mutants resistant to amethopterin presenting a change in the anti-metabolite transport system].

Authors:  M C Trombe; A M Sicard
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1973-06-25

10.  Genetically alterable transport of amethopterin in Diplococcus pneumoniae. I. Physiological properties and kinetics of the wild-type system.

Authors:  F M Sirotnak; M G Sargent; D J Hutchison
Journal:  J Bacteriol       Date:  1967-01       Impact factor: 3.490
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  1 in total

1.  Characterization of a Streptococcus pneumoniae mutant with altered electric transmembrane potential.

Authors:  M C Trombe; G Lanéelle; A M Sicard
Journal:  J Bacteriol       Date:  1984-06       Impact factor: 3.490
  1 in total

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