BACKGROUND: AD8 is a brief informant interview used to detect early cognitive change. This study evaluated the diagnostic performance of the participant-rated AD8 (p-AD8) in a predominantly Chinese population. METHODS: Data on demographics, clinical, and cognitive features were collected from 73 participants with no cognitive impairment (NCI), 27 participants with mild cognitive impairments, and 78 participants with Alzheimer's disease-informant dyads. Agreement and discriminative properties of p-AD8 were assessed. RESULTS: AD8 scores were associated with dementia severity. Participant and informant AD8 scores were moderately correlated within dementia dyads. The p-AD8 showed good diagnostic performance in differentiating between participants with NCI and participants with cognitive impairment (sensitivity = 85.0%, specificity = 74.0%, and area under the curve = 0.80), with a cutoff score of ≥1. Combination of impairment in Mini-Mental State Examination and p-AD8 is more useful in detecting cognitive impairment than using the AD8 alone. CONCLUSION: Within a transcultural setting, the p-AD8 demonstrated good discriminative validity and can be used to gain a preliminary understanding of an individual's cognitive status.
BACKGROUND:AD8 is a brief informant interview used to detect early cognitive change. This study evaluated the diagnostic performance of the participant-rated AD8 (p-AD8) in a predominantly Chinese population. METHODS: Data on demographics, clinical, and cognitive features were collected from 73 participants with no cognitive impairment (NCI), 27 participants with mild cognitive impairments, and 78 participants with Alzheimer's disease-informant dyads. Agreement and discriminative properties of p-AD8 were assessed. RESULTS:AD8 scores were associated with dementia severity. Participant and informant AD8 scores were moderately correlated within dementia dyads. The p-AD8 showed good diagnostic performance in differentiating between participants with NCI and participants with cognitive impairment (sensitivity = 85.0%, specificity = 74.0%, and area under the curve = 0.80), with a cutoff score of ≥1. Combination of impairment in Mini-Mental State Examination and p-AD8 is more useful in detecting cognitive impairment than using the AD8 alone. CONCLUSION: Within a transcultural setting, the p-AD8 demonstrated good discriminative validity and can be used to gain a preliminary understanding of an individual's cognitive status.
Authors: John E Morley; John C Morris; Marla Berg-Weger; Soo Borson; Brian D Carpenter; Natalia Del Campo; Bruno Dubois; Keith Fargo; L Jaime Fitten; Joseph H Flaherty; Mary Ganguli; George T Grossberg; Theodore K Malmstrom; Ronald D Petersen; Carroll Rodriguez; Andrew J Saykin; Philip Scheltens; Eric G Tangalos; Joe Verghese; Gordon Wilcock; Bengt Winblad; Jean Woo; Bruno Vellas Journal: J Am Med Dir Assoc Date: 2015-09-01 Impact factor: 4.669
Authors: Jesse S Passler; Richard E Kennedy; Michael Crowe; Olivio J Clay; Virginia J Howard; Mary Cushman; Frederick W Unverzagt; Virginia G Wadley Journal: Arch Clin Neuropsychol Date: 2021-02-12 Impact factor: 2.813
Authors: Kirsty Hendry; Claire Green; Rupert McShane; Anna H Noel-Storr; David J Stott; Sumayya Anwer; Alex J Sutton; Jennifer K Burton; Terry J Quinn Journal: Cochrane Database Syst Rev Date: 2019-03-04