Literature DB >> 2349164

Acetonitrile ingestion: delayed onset of cyanide poisoning due to concurrent ingestion of acetone.

M D Boggild1, R W Peck, C R Tomson.   

Abstract

A fatal case of acetonitrile ingestion is reported. The patient presented having apparently taken an overdose but was well until around 24 hours after the supposed ingestion, when cardiovascular collapse and profound metabolic acidosis developed. Later investigation revealed that the patient had taken acetone and acetonitrile. Acetone is known to slow the metabolism of acetonitrile to cyanide, thereby delaying the appearance of toxicity.

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Year:  1990        PMID: 2349164      PMCID: PMC2429384          DOI: 10.1136/pgmj.66.771.40

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN: 0032-5473            Impact factor:   2.401


  6 in total

1.  Accidental group exposure to acetonitrile--a clinical study.

Authors:  M L AMDUR
Journal:  J Occup Med       Date:  1959-12

2.  Acute volontary intoxication by acetonitrile.

Authors:  A Jaeger; J D Tempe; A Porte; L Stoeckel; J M Mantz
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1977

3.  [Poisoning by acetonitrile. A lethal case].

Authors:  J Dequidt; D Furon; F Wattle; J M Haguenoer; P Scherpereel; B Gosselin; A Ginestet
Journal:  Eur J Toxicol Environ Hyg       Date:  1974 Mar-Apr

Review 4.  Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic.

Authors:  E M Caravati; T L Litovitz
Journal:  JAMA       Date:  1988-12-16       Impact factor: 56.272

5.  Acetone potentiation of acute acetonitrile toxicity in rats.

Authors:  J J Freeman; E P Hayes
Journal:  J Toxicol Environ Health       Date:  1985

6.  Inhalation toxicology of acute exposure to aliphatic nitriles.

Authors:  C C Willhite
Journal:  Clin Toxicol       Date:  1981-08       Impact factor: 4.467

  6 in total
  1 in total

1.  Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.

Authors:  Janna H Villano; Charles W O'Connell; Binh T Ly; Aaron Schneir
Journal:  J Med Toxicol       Date:  2015-09
  1 in total

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