PURPOSE: Pneumoperitoneum (Pp) at 12 to 15 mmHg in rats is associated with kidney damage. However, Pp at 8 mmHg is now known to best correlate to working pressures used in humans. Thus the aim of this work was to study the kidney of rats submitted to prolonged Pp at 8 mmHg. MATERIALS AND METHODS: Rats were divided into a Sham group (n = 14), submitted to anesthesia, and a Pp group (n = 14), submitted to Pp at 8 mmHg, followed by deflation. In both groups, 7 animals were immediately killed and their kidneys were used for oxidative stress analyses. The remaining 7 rats in each group were evaluated after 6 weeks for the number of glomeruli and podocyte morphology. RESULTS: For all analyzed parameters Sham and Pp groups presented no statistical difference. CONCLUSION: When submitted to adequate Pp pressures (8 mmHg), no kidney damage occurs in rats.
PURPOSE: Pneumoperitoneum (Pp) at 12 to 15 mmHg in rats is associated with kidney damage. However, Pp at 8 mmHg is now known to best correlate to working pressures used in humans. Thus the aim of this work was to study the kidney of rats submitted to prolonged Pp at 8 mmHg. MATERIALS AND METHODS:Rats were divided into a Sham group (n = 14), submitted to anesthesia, and a Pp group (n = 14), submitted to Pp at 8 mmHg, followed by deflation. In both groups, 7 animals were immediately killed and their kidneys were used for oxidative stress analyses. The remaining 7 rats in each group were evaluated after 6 weeks for the number of glomeruli and podocyte morphology. RESULTS: For all analyzed parameters Sham and Pp groups presented no statistical difference. CONCLUSION: When submitted to adequate Pp pressures (8 mmHg), no kidney damage occurs in rats.
Authors: José A Damasceno-Ferreira; Leonardo A S Abreu; Gustavo R Bechara; Waldemar S Costa; Marco A Pereira-Sampaio; Francisco J B Sampaio; Diogo B De Souza Journal: BMC Urol Date: 2018-03-06 Impact factor: 2.264
Authors: Daniel H Zidde; Francisco J B Sampaio; Paulo de Souza-Junior; Diogo B de Souza; Marco A Pereira-Sampaio Journal: Int Braz J Urol Date: 2020 Nov-Dec Impact factor: 1.541