OBJECTIVE: To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL). METHODS: A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI > 6 months. RESULTS: Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI > 6 months; p = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96-3.22, p = 0.067). CONCLUSIONS: Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.
OBJECTIVE: To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL). METHODS: A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI > 6 months. RESULTS:Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI > 6 months; p = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96-3.22, p = 0.067). CONCLUSIONS: Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.
Authors: Karen C Schliep; Emily M Mitchell; Sunni L Mumford; Rose G Radin; Shvetha M Zarek; Lindsey Sjaarda; Enrique F Schisterman Journal: Obstet Gynecol Date: 2016-02 Impact factor: 7.661
Authors: Luchin F Wong; Karen C Schliep; Robert M Silver; Sunni L Mumford; Neil J Perkins; Aijun Ye; Noya Galai; Jean Wactawski-Wende; Anne M Lynch; Janet M Townsend; David Faraggi; Enrique F Schisterman Journal: Am J Obstet Gynecol Date: 2014-09-20 Impact factor: 8.661
Authors: Bareng A S Nonyane; Maureen Norton; Nazma Begum; Rasheduzzaman M Shah; Dipak K Mitra; Gary L Darmstadt; Abdullah H Baqui Journal: BMC Pregnancy Childbirth Date: 2019-02-09 Impact factor: 3.007