BACKGROUND: Vitamin D receptor (VDR) gene polymorphisms have been studied as candidate variants that affect psoriasis risk. However, results have been conflicting. METHODS: We reviewed studies on VDR polymorphisms and psoriasis risk published to October 1, 2011, and quantitatively summarized associations of the most widely studied variants (FokI, TaqI, ApaI, BsmI) using meta-analysis. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals (CIs). RESULTS: Eleven eligible studies, encompassing 1106 cases and 1209 controls, were retrieved from electronic databases and included in this review. The results were heterogeneous, which may be partly explained by small sample bias, the phenomenon of winner's curse, and differences among populations. For FokI and ApaI polymorphisms, we did not find any evidence of association. A borderline allelic association was found for the BsmI B variant after exclusion of the earliest significant report (OR = 0.81, 95% CI 0.68-0.98; P = 0.04, inconsistency index [I2] = 12.7%). Among Caucasian subjects, the TaqI t allele was nominally associated with psoriasis risk (OR = 0.77, 95% CI 0.64-0.97; P = 0.012, I (2) = 0), with homozygous carriers (tt vs. TT, OR = 0.59, 95% CI 0.39-0.90; P = 0.01, I2 = 0) and recessive model (tt vs. Tt + TT, OR = 0.66, 95% CI 0.44-0.98; P = 0.04, I2 = 0) as protective factors. None of these associations persisted after adjustment for multiple comparisons. No publication bias was detected in this meta-analysis. CONCLUSIONS: No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.
BACKGROUND:Vitamin D receptor (VDR) gene polymorphisms have been studied as candidate variants that affect psoriasis risk. However, results have been conflicting. METHODS: We reviewed studies on VDR polymorphisms and psoriasis risk published to October 1, 2011, and quantitatively summarized associations of the most widely studied variants (FokI, TaqI, ApaI, BsmI) using meta-analysis. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals (CIs). RESULTS: Eleven eligible studies, encompassing 1106 cases and 1209 controls, were retrieved from electronic databases and included in this review. The results were heterogeneous, which may be partly explained by small sample bias, the phenomenon of winner's curse, and differences among populations. For FokI and ApaI polymorphisms, we did not find any evidence of association. A borderline allelic association was found for the BsmI B variant after exclusion of the earliest significant report (OR = 0.81, 95% CI 0.68-0.98; P = 0.04, inconsistency index [I2] = 12.7%). Among Caucasian subjects, the TaqI t allele was nominally associated with psoriasis risk (OR = 0.77, 95% CI 0.64-0.97; P = 0.012, I (2) = 0), with homozygous carriers (tt vs. TT, OR = 0.59, 95% CI 0.39-0.90; P = 0.01, I2 = 0) and recessive model (tt vs. Tt + TT, OR = 0.66, 95% CI 0.44-0.98; P = 0.04, I2 = 0) as protective factors. None of these associations persisted after adjustment for multiple comparisons. No publication bias was detected in this meta-analysis. CONCLUSIONS: No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.
Authors: Roger Bouillon; Claudio Marcocci; Geert Carmeliet; Daniel Bikle; John H White; Bess Dawson-Hughes; Paul Lips; Craig F Munns; Marise Lazaretti-Castro; Andrea Giustina; John Bilezikian Journal: Endocr Rev Date: 2019-08-01 Impact factor: 19.871
Authors: Amal Ahmed Mohamed; Eman Elhussain; Naglaa Fawzy; Yasser Sakr; Marwa Salah El-Dien; Abbas Mohammed Abbas; Maha S Hussein; Nourelhuda Nassar; Omnia Ezzat; Reham Yousry El-Amir; Sarah Ibrahim; Nermeen Ibrahim Bedair Journal: Clin Cosmet Investig Dermatol Date: 2022-07-07
Authors: Massimo De Martinis; Lia Ginaldi; Maria Maddalena Sirufo; Enrica Maria Bassino; Francesca De Pietro; Giovanni Pioggia; Sebastiano Gangemi Journal: Front Immunol Date: 2021-01-08 Impact factor: 7.561