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Literature DB >> 23487462

The p53 protein does not facilitate adenovirus type 5 replication in normal human cells.

Abstract

Although several adenovirus type 5 (Ad5) proteins prevent deleterious consequences of activation of p53, it has been reported that viral replication proceeds more efficiently when human tumor cells produce wild-type compared to mutant p53. We have now exploited RNA interference and lentiviral vectors to achieve essentially complete knockdown of p53 in normal human cells: no effects on the kinetics or efficiency of viral gene expression or production of infectious particles were observed.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23487462 PMCID： PMC3648133 DOI： 10.1128/JVI.00129-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

Authors: L Rao; M Debbas; P Sabbatini; D Hockenbery; S Korsmeyer; E White
Journal: Proc Natl Acad Sci U S A Date: 1992-08-15 Impact factor: 11.205

2. Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.

Authors: Jasdave S Chahal; S J Flint
Journal: J Virol Date: 2012-01-25 Impact factor: 5.103

3. Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts.

Authors: Ramon Gonzalez; Wenying Huang; Renee Finnen; Courtney Bragg; S J Flint
Journal: J Virol Date: 2006-01 Impact factor: 5.103

4. Design and Cloning of an shRNA into a Lentiviral Silencing Vector: Version B.

Authors: Gustavo Tiscornia; Oded Singer; Inder M Verma
Journal: CSH Protoc Date: 2008-08-01

5. The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.

Authors: W T Steegenga; N Riteco; A G Jochemsen; F J Fallaux; J L Bos
Journal: Oncogene Date: 1998-01-22 Impact factor: 9.867

6. Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.

Authors: E Querido; M R Morrison; H Chu-Pham-Dang; S W Thirlwell; D Boivin; P E Branton; M R Morisson
Journal: J Virol Date: 2001-01 Impact factor: 5.103

Review 7. Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis.

Authors: E White
Journal: Cell Death Differ Date: 2006-05-05 Impact factor: 15.828

8. Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block.

Authors: J S Mymryk; K Shire; S T Bayley
Journal: Oncogene Date: 1994-04 Impact factor: 9.867

9. The temporal order of genetic and pathway alterations in tumorigenesis.

Authors: Moritz Gerstung; Nicholas Eriksson; Jimmy Lin; Bert Vogelstein; Niko Beerenwinkel
Journal: PLoS One Date: 2011-11-01 Impact factor: 3.240

10. The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.

Authors: Jasdave S Chahal; Ji Qi; S J Flint
Journal: PLoS Pathog Date: 2012-08-09 Impact factor: 6.823

5 in total

The p53 protein does not facilitate adenovirus type 5 replication in normal human cells.

1. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

2. Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.

3. Adenovirus E1B 55-kilodalton protein is required for both regulation of mRNA export and efficient entry into the late phase of infection in normal human fibroblasts.

4. Design and Cloning of an shRNA into a Lentiviral Silencing Vector: Version B.

5. The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.

6. Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.

Review 7. Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis.

8. Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block.

9. The temporal order of genetic and pathway alterations in tumorigenesis.

10. The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.

1. Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.

2. Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein.

3. Adenovirus 5 E1A-Mediated Suppression of p53 via FUBP1.

Review 4. Metabolic Control by DNA Tumor Virus-Encoded Proteins.

5. The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53.