Histophysiology of immune system and barrier organs in the late period of orchiectomy in Wistar rats.

We studied the histological and physiological changes in the organs of the immune system, liver, and lungs as well as colon microflora in the late period after orchiectomy in Wistar rats. It was shown that on day 52 after surgical castration leading to a sharp decline in androgens, activation of the immune system was detected with enhanced production of IL-12 and IL-6 and accumulation of neutrophils in the interalveolar septa of the lungs. The level of aspartate aminotransferase was within the normal range. Qualitative and quantitative changes of microflora were associated with increased number of opportunistic bacteria.