| Literature DB >> 23486571 |
V V Kolobov1, I A Zakharova, V G Fomina, V Yu Gorbatov, T V Davydova.
Abstract
Experiments on rats have showed that neurodegenerative damage to the brain induced by injection of a neurotoxic β-amyloid protein fragment β25-35into the basal giant cell nuclei of Meynert activated caspase-3 in the prefrontal cortex and hippocampus on day 3 after injury. Intranasal administration of antibodies to glutamate in a dose of 300 μ g/kg 1 h after damage reduced enzyme activity in these structures in a rat model of Alzheimer's disease.Entities:
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Year: 2013 PMID： 23486571 DOI： 10.1007/s10517-013-1967-x
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804