P Pastides1, M Chimutengwende-Gordon, N Maffulli, W Khan. 1. University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, United Kingdom. ppastides@hotmail.com
Abstract
OBJECTIVES: The use of stem cell therapy for the repair of cartilage defects has shown promising results in in vitro and animal studies. However, only a small number of studies have been performed to evaluate the benefits in human subjects. The aim of this study is to systematically review studies that focus on the clinical application of stem cell therapy to treat cartilage defects in human subjects. DESIGN: A literature search was performed, adhering to the PRISMA guidelines, to review any studies using such techniques in humans. Our initial search retrieved 105 articles listed on MEDLINE, EMBASE, Google Scholar, CINHal and SPortDiscus. From these studies, 11 studies meeting the eligibility criteria were selected and formed the basis of our systematic review. RESULTS: There is limited evidence showing the benefit in humans. The study designs, follow-up methods and criteria reporting and evaluation vary greatly between the studies and are outlined in our systematic review. CONCLUSION: With an increasing body of evidence in non-human and in vitro studies, more human trials are required. More high level studies with extensive and robust validated reporting methods should be conducted to evaluate the true effect of such techniques in human cartilage defect repairs.
OBJECTIVES: The use of stem cell therapy for the repair of cartilage defects has shown promising results in in vitro and animal studies. However, only a small number of studies have been performed to evaluate the benefits in human subjects. The aim of this study is to systematically review studies that focus on the clinical application of stem cell therapy to treat cartilage defects in human subjects. DESIGN: A literature search was performed, adhering to the PRISMA guidelines, to review any studies using such techniques in humans. Our initial search retrieved 105 articles listed on MEDLINE, EMBASE, Google Scholar, CINHal and SPortDiscus. From these studies, 11 studies meeting the eligibility criteria were selected and formed the basis of our systematic review. RESULTS: There is limited evidence showing the benefit in humans. The study designs, follow-up methods and criteria reporting and evaluation vary greatly between the studies and are outlined in our systematic review. CONCLUSION: With an increasing body of evidence in non-human and in vitro studies, more human trials are required. More high level studies with extensive and robust validated reporting methods should be conducted to evaluate the true effect of such techniques in humancartilage defect repairs.
Authors: David A Brindley; Anna French; Jane Suh; MacKenna Roberts; Benjamin Davies; Rafael Pinedo-Villanueva; Karolina Wartolowska; Kelly Rooke; Anneke Kramm; Andrew Judge; Mark Morrey; Amit Chandra; Hannah Hurley; Liam Grover; Ian Bingham; Bernard Siegel; Matt S Rattley; R Lee Buckler; David McKeon; Katie Krumholz; Lilian Hook; Michael May; Sarah Rikabi; Rosie Pigott; Megan Morys; Afsie Sabokbar; Emily Titus; Yacine Laabi; Gilles Lemaitre; Raymond Zahkia; Doug Sipp; Robert Horne; Christopher Bravery; David Williams; Ivan Wall; Evan Y Snyder; Jeffrey M Karp; Richard W Barker; Kim Bure; Andrew J Carr; Brock Reeve Journal: Stem Cells Dev Date: 2013-12 Impact factor: 3.272
Authors: Laurie R Goodrich; Albert C Chen; Natasha M Werpy; Ashley A Williams; John D Kisiday; Alvin W Su; Esther Cory; Paul S Morley; C Wayne McIlwraith; Robert L Sah; Constance R Chu Journal: J Bone Joint Surg Am Date: 2016-01-06 Impact factor: 5.284