| Literature DB >> 23485725 |
Sun Kyung Kim1, Cheol-Heui Yun, Seung Hyun Han.
Abstract
Properly sensitized dendritic cells (DCs) can be an effective immunotherapeutic against cancers. We investigated the phenotypic and functional changes in human DCs sensitized with γ-irradiated colon cancer cell-line HT-29 (GIH). GIH induced maturation and activation of DCs. GIH-sensitized DCs showed increased cytotoxic activity against HT-29 through higher expression of perforin and granzyme B. They further induced expression of effector cytokines, cytotoxic molecules, and mucosal-homing receptor in autologous T-cells. Conclusively, these results suggest that effective anti-cancer activity is induced when DCs are sensitized with γ-irradiated cancer cells via both direct augmentation of the cytotoxicity and indirect activation of T cells.Entities:
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Year: 2013 PMID： 23485725 DOI： 10.1016/j.canlet.2013.02.038
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679