BACKGROUND: Previous studies on dietary magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual magnesium uptake. Urinary excretion of magnesium, an indicator of dietary magnesium uptake, might provide more consistent results. OBJECTIVE: The objective was to investigate whether urinary magnesium excretion and plasma magnesium are associated with IHD risk. DESIGN: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study-a prospective population-based cohort study. Urinary magnesium excretion was measured in 2 baseline 24-h urine collections. RESULTS: Mean ± SD urinary magnesium excretion was 4.24 ± 1.65 mmol/24 h for men and 3.54 ± 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary magnesium excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: <2.93 mmol/24 h; women: <2.45 mmol/24 h) had an increased risk of fatal and nonfatal IHD (multivariable HR: 1.60; 95% CI: 1.28, 2.00) compared with the upper 4 quintiles of urinary magnesium excretion. A similar increase in risk of the lowest quintile was observed for mortality related to IHD (HR: 1.70; 95% CI: 1.10, 2.61). No associations were observed between circulating magnesium and risk of IHD. CONCLUSIONS: Low urinary magnesium excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of magnesium, particularly in those with the lowest urinary magnesium, could reduce the risk of IHD.
BACKGROUND: Previous studies on dietary magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual magnesium uptake. Urinary excretion of magnesium, an indicator of dietary magnesium uptake, might provide more consistent results. OBJECTIVE: The objective was to investigate whether urinary magnesium excretion and plasma magnesium are associated with IHD risk. DESIGN: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study-a prospective population-based cohort study. Urinary magnesium excretion was measured in 2 baseline 24-h urine collections. RESULTS: Mean ± SD urinary magnesium excretion was 4.24 ± 1.65 mmol/24 h for men and 3.54 ± 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary magnesium excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: <2.93 mmol/24 h; women: <2.45 mmol/24 h) had an increased risk of fatal and nonfatal IHD (multivariable HR: 1.60; 95% CI: 1.28, 2.00) compared with the upper 4 quintiles of urinary magnesium excretion. A similar increase in risk of the lowest quintile was observed for mortality related to IHD (HR: 1.70; 95% CI: 1.10, 2.61). No associations were observed between circulating magnesium and risk of IHD. CONCLUSIONS: Low urinary magnesium excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of magnesium, particularly in those with the lowest urinary magnesium, could reduce the risk of IHD.
Authors: Rebecca B Costello; Ronald J Elin; Andrea Rosanoff; Taylor C Wallace; Fernando Guerrero-Romero; Adela Hruby; Pamela L Lutsey; Forrest H Nielsen; Martha Rodriguez-Moran; Yiqing Song; Linda V Van Horn Journal: Adv Nutr Date: 2016-11-15 Impact factor: 8.701
Authors: Sally N Adebamowo; Monik C Jiménez; Stephanie E Chiuve; Donna Spiegelman; Walter C Willett; Kathryn M Rexrode Journal: Stroke Date: 2014-08-12 Impact factor: 7.914
Authors: Mary R Rooney; Alvaro Alonso; Aaron R Folsom; Erin D Michos; Casey M Rebholz; Jeffrey R Misialek; Lin Yee Chen; Samuel Dudley; Pamela L Lutsey Journal: Am J Clin Nutr Date: 2020-01-01 Impact factor: 7.045
Authors: Tanguy Corre; Francisco J Arjona; Caroline Hayward; Sonia Youhanna; Jeroen H F de Baaij; Hendrica Belge; Nadine Nägele; Huguette Debaix; Maxime G Blanchard; Michela Traglia; Sarah E Harris; Sheila Ulivi; Rico Rueedi; David Lamparter; Aurélien Macé; Cinzia Sala; Stefania Lenarduzzi; Belen Ponte; Menno Pruijm; Daniel Ackermann; Georg Ehret; Daniela Baptista; Ozren Polasek; Igor Rudan; Toby W Hurd; Nicholas D Hastie; Veronique Vitart; Geràrd Waeber; Zoltán Kutalik; Sven Bergmann; Rosa Vargas-Poussou; Martin Konrad; Paolo Gasparini; Ian J Deary; John M Starr; Daniela Toniolo; Peter Vollenweider; Joost G J Hoenderop; René J M Bindels; Murielle Bochud; Olivier Devuyst Journal: J Am Soc Nephrol Date: 2017-11-01 Impact factor: 10.121