MR spectroscopy of head and neck cancer.

The aim of this review is to discuss the technique and potential applications of magnetic resonance spectroscopy (MRS) in head and neck cancer. We illustrate the technical issues related to data acquisition, post processing and interpretation of MRS of head and neck lesions. MRS has been used for differentiation of squamous cell carcinoma from normal tissue. The main potential clinical application of proton MRS ((1)H-MRS) is monitoring patients with head and neck cancer undergoing therapy. Pretreatment prediction of response to therapy can be done with phosphorus MRS ((31)P-MRS). Although performance of MRS of head and neck is challenging, technological advances in both software and hardware has the potential to impact on the clinical management of patients with head and neck cancer.