Warren Rjd Galloway1, David R Spring. 1. University of Cambridge, The University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK +44 0 1223 336498 ; +44 0 1223 336362 ; drspring@ch.cam.ac.uk.
Abstract
BACKGROUND: 'Diversity' is often cited as a crucial consideration when generating compound collections for biological screening. However, what exactly does one mean by 'diversity' and why is it important? OBJECTIVE: How can diversity be incorporated into compound collections and what are the theoretical and technical challenges this poses? In this editorial, we comment on various factors involved in the creation of structurally, and most crucially, functionally diverse compound libraries. CONCLUSIONS: In particular, we highlight the central role played by organic synthesis and discuss the value of diversity-driven synthetic approaches in the search for new biologically active molecules with potentially exciting and unusual biological properties.
BACKGROUND: 'Diversity' is often cited as a crucial consideration when generating compound collections for biological screening. However, what exactly does one mean by 'diversity' and why is it important? OBJECTIVE: How can diversity be incorporated into compound collections and what are the theoretical and technical challenges this poses? In this editorial, we comment on various factors involved in the creation of structurally, and most crucially, functionally diverse compound libraries. CONCLUSIONS: In particular, we highlight the central role played by organic synthesis and discuss the value of diversity-driven synthetic approaches in the search for new biologically active molecules with potentially exciting and unusual biological properties.
Authors: Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring Journal: Proc Natl Acad Sci U S A Date: 2011-03-07 Impact factor: 11.205
Authors: Yubing Si; David Xu; Khuchtumur Bum-Erdene; Mona K Ghozayel; Baocheng Yang; Paul A Clemons; Samy O Meroueh Journal: ChemMedChem Date: 2018-12-20 Impact factor: 3.466
Authors: Thomas A King; Hannah L Stewart; Kim T Mortensen; Andrew J P North; Hannah F Sore; David R Spring Journal: European J Org Chem Date: 2019-07-29