Literature DB >> 2348425

Clinical significance of IgG anti-Sm antibodies in patients with systemic lupus erythematosus.

M Yasuma1, Y Takasaki, K Matsumoto, A Kodama, H Hashimoto, S Hirose.   

Abstract

Free Sm was purified by gel filtration and anti-Sm affinity chromatography. Using this purified antigen, an ELISA for anti-Sm was performed. Three hundred and fifty patients with various rheumatic diseases were studied with respect to immunoglobulin classes of anti-Sm by ELISA. A high frequency of IgG anti-Sm was specifically detected in patients with systemic lupus erythematosus (SLE), but IgA and IgM anti-Sm showed a low frequency and also was detected in other diseases. In patients with SLE, anti-Sm significantly correlated with lung fibrosis and pericarditis. In our longitudinal study, there were increases in titer of IgG anti-Sm preceding central nervous system exacerbation and serositis. IgG anti-Sm was found to be not only a diagnostic marker but also a reliable measure of disease activity in SLE.

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Year:  1990        PMID： 2348425

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  15 in total

Review 1.  The use of laboratory tests in the diagnosis of SLE.

Authors:  W Egner
Journal:  J Clin Pathol       Date:  2000-06       Impact factor: 3.411

Review 2.  Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.

Authors:  R A Eisenberg
Journal:  Springer Semin Immunopathol       Date:  1992

Review 3.  Antinuclear antibodies to RNA-binding proteins in SLE.

Authors:  P J Maddison
Journal:  Rheumatol Int       Date:  1991       Impact factor: 2.631

4.  Autoantibodies in black South Africans with systemic lupus erythematosus: spectrum and clinical associations.

Authors:  M Tikly; S Burgin; P Mohanlal; A Bellingan; J George
Journal:  Clin Rheumatol       Date:  1996-05       Impact factor: 2.980

5.  Autoantibodies in black South Africans with systemic lupus erythematosus: spectrum and clinical associations.

Authors:  M Tikly; S Burgin; P Mohanlal; A Bellingan; J George
Journal:  Clin Rheumatol       Date:  1996-03       Impact factor: 2.980

Review 6.  Clinical relevance of autoantibodies in systemic rheumatic diseases.

Authors:  M J Fritzler
Journal:  Mol Biol Rep       Date:  1996       Impact factor: 2.316

7.  Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort.

Authors:  Mariangelí Arroyo-Ávila; Yesenia Santiago-Casas; Gerald McGwin; Ryan S Cantor; Michelle Petri; Rosalind Ramsey-Goldman; John D Reveille; Robert P Kimberly; Graciela S Alarcón; Luis M Vilá; Elizabeth E Brown
Journal:  Clin Rheumatol       Date:  2015-04-22       Impact factor: 2.980

8.  A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus.

Authors:  G Riemekasten; J Marell; G Trebeljahr; R Klein; G Hausdorf; T Häupl; J Schneider-Mergener; G R Burmester; F Hiepe
Journal:  J Clin Invest       Date:  1998-08-15       Impact factor: 14.808

9.  Antibodies to Sm and SS-A demonstrated by enzyme immunoassay. Correlation to clinical manifestations and disease activity in patients with systemic lupus erythematosus.

Authors:  M Gripenberg; A M Teppo; C Friman
Journal:  Rheumatol Int       Date:  1991       Impact factor: 2.631

10.  Study on clinical features and complications with systemic lupus erythematosus (SLE) activity in Chinese Han population.

Authors:  Lian Hong Li; Hai Feng Pan; Wen Xian Li; Xiang Pei Li; Jian Hua Xu; Dong Qing Ye
Journal:  Clin Rheumatol       Date:  2009-08-07       Impact factor: 2.980
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