INTRODUCTION: EBV has been a leading candidate as a trigger for several autoimmune diseases. We describe an antineutrophil cytoplasmic autoantibody (ANCA) -associated systemic vasculitis as the initial presenting illness of AIDS. CASE REPORT AND RESULTS: The patient was diagnosed ANCA -associated systemic vasculitis in the setting of HIV infection because of a high level of ANCA level, crescent glomerulonephritis in pathology, and clinical signs and symptoms compatible with systemic vasculitis. He also had HIV associated lymphadenopathy with scattered. EBV-RNA positive cells and reactive germinal centers. CONCLUSION: EBV genome was found in reactive lymph nodes and, therefore, may be associated with the immunopathogenesis of vasculitis.
INTRODUCTION:EBV has been a leading candidate as a trigger for several autoimmune diseases. We describe an antineutrophil cytoplasmic autoantibody (ANCA) -associated systemic vasculitis as the initial presenting illness of AIDS. CASE REPORT AND RESULTS: The patient was diagnosed ANCA -associated systemic vasculitis in the setting of HIV infection because of a high level of ANCA level, crescent glomerulonephritis in pathology, and clinical signs and symptoms compatible with systemic vasculitis. He also had HIV associated lymphadenopathy with scattered. EBV-RNA positive cells and reactive germinal centers. CONCLUSION:EBV genome was found in reactive lymph nodes and, therefore, may be associated with the immunopathogenesis of vasculitis.
Authors: R Dolcetti; A Gloghini; S De Vita; E Vaccher; V De Re; U Tirelli; A Carbone; M Boiocchi Journal: Int J Cancer Date: 1995-11-27 Impact factor: 7.396