OBJECTIVES: The aim of this study was to verify human papillomavirus (HPV) transmission and genotype concordance among heterosexual couples. MATERIALS AND METHODS: Thirty-one married couples were evaluated. All male subjects presented with clinically diagnosed HPV-related malignant or potentially malignant lesions and underwent peniscopy and penile swab. Their female counterparts underwent swabs of the uterine cervix and oral mucosa. HPV-DNA detection was performed by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: HPV-DNA was detected in the penis, vagina/cervix, and oral cavity of 16 couples (51.61%). Of these, HPV-DNA concordance was observed in 14 couples (87.5%). HPV-DNA was amplified in penile and oral sites of 14 couples. Of these, 13 couples reported fellatio (92.85%), most of them (10 couples, 76.9%) without condom use. HPV-DNA concordance was observed in 7/10 of these couples (70%). The three couples (100%) who reported use of condom during fellatio were HPV-DNA discordant (p = 0.025). CONCLUSIONS: Lifetime number of female sexual partners and detection of HPV-DNA in the penile mucosa are surrogate markers of exposure to HPV during marriage. Consistent use of condoms may reduce the risk of HPV transmission. CLINICAL RELEVANCE: Oral acquisition of HPV from oro-genital contact is influenced by lack of condom use and previous sexual behavior of the male partner. In addition, oral transmission of the virus due to fellatio is as common as genital transmission.
OBJECTIVES: The aim of this study was to verify human papillomavirus (HPV) transmission and genotype concordance among heterosexual couples. MATERIALS AND METHODS: Thirty-one married couples were evaluated. All male subjects presented with clinically diagnosed HPV-related malignant or potentially malignant lesions and underwent peniscopy and penile swab. Their female counterparts underwent swabs of the uterine cervix and oral mucosa. HPV-DNA detection was performed by polymerase chain reaction and restriction fragment length polymorphism. RESULTS:HPV-DNA was detected in the penis, vagina/cervix, and oral cavity of 16 couples (51.61%). Of these, HPV-DNA concordance was observed in 14 couples (87.5%). HPV-DNA was amplified in penile and oral sites of 14 couples. Of these, 13 couples reported fellatio (92.85%), most of them (10 couples, 76.9%) without condom use. HPV-DNA concordance was observed in 7/10 of these couples (70%). The three couples (100%) who reported use of condom during fellatio were HPV-DNA discordant (p = 0.025). CONCLUSIONS: Lifetime number of female sexual partners and detection of HPV-DNA in the penile mucosa are surrogate markers of exposure to HPV during marriage. Consistent use of condoms may reduce the risk of HPV transmission. CLINICAL RELEVANCE: Oral acquisition of HPV from oro-genital contact is influenced by lack of condom use and previous sexual behavior of the male partner. In addition, oral transmission of the virus due to fellatio is as common as genital transmission.
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Authors: M I Hippeläinen; M Yliskoski; S Syrjänen; J Saastamoinen; M Hippeläinen; S Saarikoski; K Syrjänen Journal: Sex Transm Dis Date: 1994 Mar-Apr Impact factor: 2.830
Authors: R D Burk; P Kelly; J Feldman; J Bromberg; S H Vermund; J A DeHovitz; S H Landesman Journal: Sex Transm Dis Date: 1996 Jul-Aug Impact factor: 2.830
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Authors: S Deblina Datta; Laura A Koutsky; Sylvie Ratelle; Elizabeth R Unger; Judith Shlay; Tracie McClain; Beth Weaver; Peter Kerndt; Jonathan Zenilman; Michael Hagensee; Cristen J Suhr; Hillard Weinstock Journal: Ann Intern Med Date: 2008-04-01 Impact factor: 25.391
Authors: Kari Syrjänen; Irena Shabalova; Nicolay Petrovichev; Vladimir Kozachenko; Tatjana Zakharova; Julia Pajanidi; Jurij Podistov; Galina Chemeris; Larisa Sozaeva; Elena Lipova; Irena Tsidaeva; Olga Ivanchenko; Alla Pshepurko; Sergej Zakharenko; Raisa Nerovjna; Ludmila Kljukina; Oksana Erokhina; Marina Branovskaja; Maritta Nikitina; Valerija Grunberga; Alexandr Grunberg; Anna Juschenko; Rosa Santopietro; Marcella Cintorino; Piero Tosi; Stina Syrjänen Journal: Eur J Epidemiol Date: 2007-09-08 Impact factor: 12.434
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