AIM: To examine the usefulness of the histopathological finding of tumor necrosis for stratifying TNM stage IV colorectal cancer in R0 status. PATIENTS AND METHODS: We enrolled 98 patients with stage IV colorectal cancer, without residual disease after resection. The extent of necrosis was assessed using published thresholds, the extent was graded as "absent", "moderate" (<30% of tumor area), or "severe" (≥30%) in each section. RESULTS: In multivariate analysis, the only significant difference in the disease-free survival rate was related to tumor necrosis (p=0.01) and the significant differences in the overall survival rates were related to the maximum tumor size and the degree of tumor necrosis (p=0.02 and p=0.001, respectively). CONCLUSION: Tumor necrosis is associated with a poor prognosis in colorectal cancer and may allow the stratification of TNM stage IV patients without residual disease after surgery.
AIM: To examine the usefulness of the histopathological finding of tumor necrosis for stratifying TNM stage IV colorectal cancer in R0 status. PATIENTS AND METHODS: We enrolled 98 patients with stage IV colorectal cancer, without residual disease after resection. The extent of necrosis was assessed using published thresholds, the extent was graded as "absent", "moderate" (<30% of tumor area), or "severe" (≥30%) in each section. RESULTS: In multivariate analysis, the only significant difference in the disease-free survival rate was related to tumor necrosis (p=0.01) and the significant differences in the overall survival rates were related to the maximum tumor size and the degree of tumor necrosis (p=0.02 and p=0.001, respectively). CONCLUSION:Tumor necrosis is associated with a poor prognosis in colorectal cancer and may allow the stratification of TNM stage IV patients without residual disease after surgery.
Authors: Suman Kumar Vodnala; Robert Eil; Rigel J Kishton; Madhusudhanan Sukumar; Tori N Yamamoto; Ngoc-Han Ha; Ping-Hsien Lee; MinHwa Shin; Shashank J Patel; Zhiya Yu; Douglas C Palmer; Michael J Kruhlak; Xiaojing Liu; Jason W Locasale; Jing Huang; Rahul Roychoudhuri; Toren Finkel; Christopher A Klebanoff; Nicholas P Restifo Journal: Science Date: 2019-03-29 Impact factor: 47.728
Authors: Jen Chun Kuan; Chang Chieh Wu; Chien An Sun; Chi Ming Chu; Fu Gong Lin; Chih Hsiung Hsu; Po-Chieh Kan; Shih-Chieh Lin; Tsan Yang; Yu-Ching Chou Journal: PLoS One Date: 2015-03-27 Impact factor: 3.240
Authors: Yi Jer Tan; Yeuan Ting Lee; Sven H Petersen; Gurjeet Kaur; Koji Kono; Soo Choon Tan; Amin M S Abdul Majid; Chern Ein Oon Journal: Ther Adv Med Oncol Date: 2019-09-27 Impact factor: 8.168