| Literature DB >> 23481651 |
Gary V Martinez1, Suryakiran Navath, Kamini Sewda, Venkataramanarao Rao, Parastou Foroutan, Ramesh Alleti, Valerie E Moberg, Ali M Ahad, Domenico Coppola, Mark C Lloyd, Robert J Gillies, David L Morse, Eugene A Mash.
Abstract
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.Entities:
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Year: 2013 PMID： 23481651 PMCID： PMC3602218 DOI： 10.1016/j.bmcl.2013.02.008
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823