| Literature DB >> 23481348 |
Charles Stewart1, Christopher R Vickery, Michael D Burkart, Joseph P Noel.
Abstract
Type III plant polyketide synthases (PKSs) biosynthesize a dazzling array of polyphenolic products that serve important roles in both plant and human health. Recent advances in structural characterization of these enzymes and new tools from the field of chemical biology have facilitated exquisite probing of plant PKS iterative catalysis. These tools have also been used to exploit type III PKSs as biocatalysts to generate new chemicals. Going forward, chemical, structural and biochemical analyses will provide an atomic resolution understanding of plant PKSs and will serve as a springboard for bioengineering and scalable production of valuable molecules in vitro, by fermentation and in planta.Entities:
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Year: 2013 PMID： 23481348 DOI： 10.1016/j.pbi.2013.02.004
Source DB: PubMed Journal: Curr Opin Plant Biol ISSN： 1369-5266 Impact factor: 7.834