Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Manufacturing mesenchymal stromal cells for phase I clinical trials.

Literature DB >> 23480951

Manufacturing mesenchymal stromal cells for phase I clinical trials.

Patrick J Hanley¹, Zhuyong Mei, Maria da Graca Cabreira-Hansen, Mariola Klis, Wei Li, Yali Zhao, April G Durett, Xingwu Zheng, Yongping Wang, Adrian P Gee, Edwin M Horwitz.

Abstract

Mesenchymal stromal cells (MSCs) are multipotent progenitor cells capable of differentiating into adipocytes, osteoblasts and chondroblasts as well as secreting a vast array of soluble mediators. This potentially makes MSCs important mediators of a variety of therapeutic applications. They are actively under evaluation for immunomodulatory purposes such as graft-versus-host disease and Crohn's disease as well as regenerative applications such as stroke and congestive heart failure. We report our method of generating clinical-grade MSCs together with suggestions gathered from manufacturing experience in our Good Manufacturing Practices facility.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23480951 PMCID： PMC3611961 DOI： 10.1016/j.jcyt.2012.09.007

Source DB: PubMed Journal: Cytotherapy ISSN： 1465-3249 Impact factor: 5.414

26 in total

1. Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood.

Authors: Song Kedong; Fan Xiubo; Liu Tianqing; Hugo M Macedo; Jiang LiLi; Fang Meiyun; Shi Fangxin; Ma Xuehu; Cui Zhanfeng
Journal: J Mater Sci Mater Med Date: 2010-10-06 Impact factor: 3.896

2. Toward closed-system culture of blood origin endothelial cells.

Authors: Stephen J Wagner; Andrew C Myrup
Journal: Transfusion Date: 2005-07 Impact factor: 3.157

3. The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering.

Authors: Robert Pytlík; David Stehlík; Tomás Soukup; Marie Kalbácová; Frantisek Rypácek; Tomás Trc; Katarína Mulinková; Petra Michnová; Linda Kideryová; Jan Zivný; Pavel Klener; Romana Veselá; Marek Trnený; Pavel Klener
Journal: Biomaterials Date: 2009-04-10 Impact factor: 12.479

4. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissue.

Authors: Martin A Vidal; Naomi J Walker; Eleonora Napoli; Dori L Borjesson
Journal: Stem Cells Dev Date: 2011-05-06 Impact factor: 3.272

5. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM.

Authors: I Müller; S Kordowich; C Holzwarth; C Spano; G Isensee; A Staiber; S Viebahn; F Gieseke; H Langer; M P Gawaz; E M Horwitz; P Conte; R Handgretinger; M Dominici
Journal: Cytotherapy Date: 2006 Impact factor: 5.414

6. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta.

Authors: E M Horwitz; D J Prockop; L A Fitzpatrick; W W Koo; P L Gordon; M Neel; M Sussman; P Orchard; J C Marx; R E Pyeritz; M K Brenner
Journal: Nat Med Date: 1999-03 Impact factor: 53.440

7. Translating research into clinical scale manufacturing of mesenchymal stromal cells.

Authors: Karen Bieback; Sven Kinzebach; Marianna Karagianni
Journal: Stem Cells Int Date: 2011-01-20 Impact factor: 5.443

8. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone.

Authors: Edwin M Horwitz; Patricia L Gordon; Winston K K Koo; Jeffrey C Marx; Michael D Neel; Rene Y McNall; Linda Muul; Ted Hofmann
Journal: Proc Natl Acad Sci U S A Date: 2002-06-25 Impact factor: 11.205

9. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials.

Authors: Bourin Philippe; Sensebé Luc; Planat-Bénard Valérie; Roncalli Jérôme; Bura-Rivière Alessandra; Casteilla Louis
Journal: Stem Cells Int Date: 2010-10-31 Impact factor: 5.443

10. Mesenchymal stem cells.

Authors: A I Caplan
Journal: J Orthop Res Date: 1991-09 Impact factor: 3.494

18 in total

1. An update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: a decade of cell therapy.

Authors: Deborah Wood; Robin Wesselschmidt; Peiman Hematti; Adrian P Gee; Cliona Rooney; Leslie Silberstein; Myriam Armant; Larry Couture; John E Wagner; David H McKenna; Derek Hei; Traci Heath Mondoro; Lisbeth Welniak; Robert Lindblad
Journal: Clin Transl Sci Date: 2014-03-21 Impact factor: 4.689

Review 2. Overcoming Challenges in Process Development of Cellular Therapies.

Authors: Steven L Highfill; David F Stroncek
Journal: Curr Hematol Malig Rep Date: 2019-08 Impact factor: 3.952

3. Soluble matrix protein is a potent modulator of mesenchymal stem cell performance.

Authors: Giselle C Yeo; Anthony S Weiss
Journal: Proc Natl Acad Sci U S A Date: 2019-01-18 Impact factor: 11.205

Review 4. Our Fat Future: Translating Adipose Stem Cell Therapy.

Authors: Rachel C Nordberg; Elizabeth G Loboa
Journal: Stem Cells Transl Med Date: 2015-07-16 Impact factor: 6.940

5. Efficient manufacturing of therapeutic mesenchymal stromal cells with the use of the Quantum Cell Expansion System.

Authors: Patrick J Hanley; Zhuyong Mei; April G Durett; Maria da Graca Cabreira-Hansen; Marie da Graca Cabreira-Harrison; Mariola Klis; Wei Li; Yali Zhao; Bing Yang; Kaushik Parsha; Osman Mir; Farhaan Vahidy; Debra Bloom; R Brent Rice; Peiman Hematti; Sean I Savitz; Adrian P Gee
Journal: Cytotherapy Date: 2014-04-13 Impact factor: 5.414

6. Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model.

Authors: Umadevi Kandalam; Toshihisa Kawai; Geeta Ravindran; Ross Brockman; Jorge Romero; Matthew Munro; Julian Ortiz; Alireza Heidari; Ron Thomas; Sajish Kuriakose; Christopher Naglieri; Shaileen Ejtemai; Steven I Kaltman
Journal: Tissue Eng Part A Date: 2020-09-18 Impact factor: 3.845

7. Optimizing the production of suspension cells using the G-Rex "M" series.

Authors: Pradip Bajgain; Roopa Mucharla; John Wilson; Dan Welch; Usanarat Anurathapan; Bitao Liang; Xiaohua Lu; Kyle Ripple; John M Centanni; Christine Hall; David Hsu; Larry A Couture; Shubhranshu Gupta; Adrian P Gee; Helen E Heslop; Ann M Leen; Cliona M Rooney; Juan F Vera
Journal: Mol Ther Methods Clin Dev Date: 2014-05-14 Impact factor: 6.698