Literature DB >> 23480249

A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.

Anne M Neumann1, Richard D Blondell, Urmo Jaanimägi, Amanda K Giambrone, Gregory G Homish, Jacqueline R Lozano, Urszula Kowalik, Mohammadreza Azadfard.   

Abstract

Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.

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Year:  2013        PMID： 23480249      PMCID： PMC3604999          DOI： 10.1080/10550887.2012.759872

Source DB:  PubMed          Journal:  J Addict Dis        ISSN： 1055-0887


  28 in total

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2.  Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study.

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6.  Acute administration of buprenorphine in humans: partial agonist and blockade effects.

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Review 7.  Safety and health policy considerations related to the use of buprenorphine/naloxone as an office-based treatment for opiate dependence.

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10.  Outpatient treatment of prescription opioid dependence: comparison of two methods.

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  28 in total

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Review 4.  Buprenorphine-naloxone therapy in pain management.

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Journal:  Anesthesiology       Date:  2014-05       Impact factor: 7.892

5.  Randomized clinical trial comparing buprenorphine/naloxone and methadone for the treatment of patients with failed back surgery syndrome and opioid addiction.

Authors:  Anne M Neumann; Richard D Blondell; Rachel A Hoopsick; Gregory G Homish
Journal:  J Addict Dis       Date:  2019-11-27

6.  Patient-reported pathways to opioid use disorders and pain-related barriers to treatment engagement.

Authors:  Scott P Stumbo; Bobbi Jo H Yarborough; Dennis McCarty; Constance Weisner; Carla A Green
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7.  Health care experiences when pain and substance use disorder coexist: "just because i'm an addict doesn't mean i don't have pain".

Authors:  Barbara St Marie
Journal:  Pain Med       Date:  2014-07-08       Impact factor: 3.750

8.  The conundrum of opioid tapering in long-term opioid therapy for chronic pain: A commentary.

Authors:  Ajay Manhapra; Albert J Arias; Jane C Ballantyne
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9.  Lipid-Lowering Therapy in HIV-Infected Patients: Relationship with Antiretroviral Agents and Impact of Substance-Related Disorders.

Authors:  Cindy Bednasz; Amneris E Luque; Barry S Zingman; Margaret A Fischl; Barbara M Gripshover; Charles S Venuto; Jie Gu; Zekun Feng; Robin DiFrancesco; Gene D Morse; Qing Ma
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10.  Pain volatility and prescription opioid addiction treatment outcomes in patients with chronic pain.

Authors:  Matthew J Worley; Keith G Heinzerling; Steven Shoptaw; Walter Ling
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