Literature DB >> 23478971

Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia.

Kensuke Shima1, Matthias Klinger, Werner Solbach, Jan Rupp.   

Abstract

Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.

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Year:  2013        PMID： 23478971      PMCID： PMC3716132          DOI： 10.1128/AAC.02211-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Transcriptome analysis of chlamydial growth during IFN-gamma-mediated persistence and reactivation.

Authors:  Robert J Belland; David E Nelson; Dezso Virok; Deborah D Crane; Daniel Hogan; Daniel Sturdevant; Wandy L Beatty; Harlan D Caldwell
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-12       Impact factor: 11.205

Review 2.  Chlamydia trachomatis persistence: an update.

Authors:  Philomène Mpiga; Madeleine Ravaoarinoro
Journal:  Microbiol Res       Date:  2005-06-01       Impact factor: 5.415

3.  Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring.

Authors:  W C Van Voorhis; L K Barrett; Y T Sweeney; C C Kuo; D L Patton
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

4.  Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88.

Authors:  Uma M Nagarajan; David M Ojcius; Lynn Stahl; Roger G Rank; Toni Darville
Journal:  J Immunol       Date:  2005-07-01       Impact factor: 5.422

Review 5.  T cell responses to Chlamydia trachomatis.

Authors:  Wendy P Loomis; Michael N Starnbach
Journal:  Curr Opin Microbiol       Date:  2002-02       Impact factor: 7.934

Review 6.  Protons make tumor cells move like clockwork.

Authors:  Christian Stock; Albrecht Schwab
Journal:  Pflugers Arch       Date:  2009-05-13       Impact factor: 3.657

7.  Characterization of in vitro chlamydial cultures in low-oxygen atmospheres.

Authors:  Nicolai Juul; Helene Jensen; Malene Hvid; Gunna Christiansen; Svend Birkelund
Journal:  J Bacteriol       Date:  2007-07-13       Impact factor: 3.490

Review 8.  Targeting HIF-1 for cancer therapy.

Authors:  Gregg L Semenza
Journal:  Nat Rev Cancer       Date:  2003-10       Impact factor: 60.716

Review 9.  Chlamydia persistence -- a tool to dissect chlamydia--host interactions.

Authors:  R V Schoborg
Journal:  Microbes Infect       Date:  2011-03-31       Impact factor: 2.700

10.  Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis.

Authors:  Nathalie Reveneau; Deborah D Crane; Elizabeth Fischer; Harlan D Caldwell
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191
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  4 in total

1.  Host immune responses after hypoxic reactivation of IFN-γ induced persistent Chlamydia trachomatis infection.

Authors:  Stefan Jerchel; Inga Kaufhold; Larissa Schuchardt; Kensuke Shima; Jan Rupp
Journal:  Front Cell Infect Microbiol       Date:  2014-04-16       Impact factor: 5.293

2.  zzm321990 Chlamydia Uses K+ Electrical Signalling to Orchestrate Host Sensing, Inter-Bacterial Communication and Differentiation.

Authors:  Susan C Andrew; Maud Dumoux; Richard D Hayward
Journal:  Microorganisms       Date:  2021-01-15

3.  Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth in vitro.

Authors:  Mark Thomas; Amba Lawrence; Samuel Kroon; Lenka A Vodstrcil; Samuel Phillips; Jane S Hocking; Peter Timms; Wilhelmina M Huston
Journal:  Access Microbiol       Date:  2021-02-19

Review 4.  Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine.

Authors:  Nicole Borel; Cory Leonard; Jessica Slade; Robert V Schoborg
Journal:  Curr Clin Microbiol Rep       Date:  2016-02-03
  4 in total

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