Literature DB >> 23478295

Proteasome-independent p53 degradation.

Mais M Nuaaman1, Samuel Benchimol.   

Abstract

The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in Cell Research identifies a proteasome-independent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.

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Year:  2013        PMID： 23478295      PMCID： PMC3641599          DOI： 10.1038/cr.2013.38

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  12 in total

1.  Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

Authors:  Jun Chen; Hua Ruan; Sok Meng Ng; Chuan Gao; Hui Meng Soo; Wei Wu; Zhenhai Zhang; Zilong Wen; David P Lane; Jinrong Peng
Journal:  Genes Dev       Date:  2005-12-01       Impact factor: 11.361

2.  p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner.

Authors:  Orit Karni-Schmidt; Andrew Zupnick; Mirela Castillo; Aqeel Ahmed; Tulio Matos; Philippe Bouvet; Carlos Cordon-Cardo; Carol Prives
Journal:  J Cell Sci       Date:  2008-11-25       Impact factor: 5.285

Review 3.  Ubiquitin-independent p53 proteasomal degradation.

Authors:  P Tsvetkov; N Reuven; Y Shaul
Journal:  Cell Death Differ       Date:  2010-01       Impact factor: 15.828

4.  Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability.

Authors:  M H Kubbutat; K H Vousden
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

5.  Proteolysis by calpains: a possible contribution to degradation of p53.

Authors:  M Pariat; S Carillo; M Molinari; C Salvat; L Debüssche; L Bracco; J Milner; M Piechaczyk
Journal:  Mol Cell Biol       Date:  1997-05       Impact factor: 4.272

6.  On the involvement of calpains in the degradation of the tumor suppressor protein p53.

Authors:  H Gonen; D Shkedy; S Barnoy; N S Kosower; A Ciechanover
Journal:  FEBS Lett       Date:  1997-04-07       Impact factor: 4.124

Review 7.  Signaling to p53: ribosomal proteins find their way.

Authors:  Yanping Zhang; Hua Lu
Journal:  Cancer Cell       Date:  2009-11-06       Impact factor: 31.743

8.  Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A.

Authors:  I Richard; O Broux; V Allamand; F Fougerousse; N Chiannilkulchai; N Bourg; L Brenguier; C Devaud; P Pasturaud; C Roudaut
Journal:  Cell       Date:  1995-04-07       Impact factor: 41.582

9.  Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.

Authors:  Carlos P Rubbi; Jo Milner
Journal:  EMBO J       Date:  2003-11-17       Impact factor: 11.598

10.  Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation.

Authors:  Ting Tao; Hui Shi; Yihong Guan; Delai Huang; Ye Chen; David P Lane; Jun Chen; Jinrong Peng
Journal:  Cell Res       Date:  2013-01-29       Impact factor: 25.617
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  3 in total

1.  Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants.

Authors:  Jana Suchánková; Soňa Legartová; Eva Ručková; Bořivoj Vojtěšek; Stanislav Kozubek; Eva Bártová
Journal:  Histochem Cell Biol       Date:  2017-04-10       Impact factor: 4.304

2.  RRP12 is a crucial nucleolar protein that regulates p53 activity in osteosarcoma cells.

Authors:  Young Joon Choi; Hye Won Lee; Yun Sun Lee; Da Mi Shim; Sung Wook Seo
Journal:  Tumour Biol       Date:  2015-10-23

3.  Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53.

Authors:  Neeraj K Aryal; Amanda R Wasylishen; Vinod Pant; Maurisa Riley-Croce; Guillermina Lozano
Journal:  Oncotarget       Date:  2017-10-26
  3 in total

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