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Literature DB >> 23477966

The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis.

Kota Moriguchi¹, Katsuichi Miyamoto, Noriko Tanaka, Osamu Yoshie, Susumu Kusunoki.

Abstract

Chemokine receptors (CCRs) play important roles in the pathogenesis of immune-mediated diseases, as well as in normal immune response. We examined the role of CCR6 and CCR4 in experimental autoimmune encephalomyelitis (EAE) by using CCR6(-/-)CCR4(-/-) double knockout (DKO) and single knockout mice. DKO mice developed less severe EAE and presented repressed recall response in the induction phase, especially in the activity of T helper 17 (Th17) cells. CCR6 expression in central nervous system (CNS)-infiltrated cells was diminished in DKO. Our results suggest that CCR6 and CCR4 were involved in a more rapid progression of EAE and that their regulation might be a therapeutic target of human inflammatory demyelinating diseases.

Entities: Disease Gene Species

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Year: 2013 PMID： 23477966 DOI： 10.1016/j.jneuroim.2013.02.002

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

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Cited

8 in total

1. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

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Journal: Sci Transl Med Date: 2015-05-13 Impact factor: 17.956

2. Generation of RORγt⁺ Antigen-Specific T Regulatory 17 Cells from Foxp3⁺ Precursors in Autoimmunity.

Authors: Byung-Seok Kim; Huiping Lu; Kenji Ichiyama; Xiang Chen; Yi-Bing Zhang; Nipun A Mistry; Kentaro Tanaka; Young-Hee Lee; Roza Nurieva; Li Zhang; Xuexian Yang; Yeonseok Chung; Wei Jin; Seon Hee Chang; Chen Dong
Journal: Cell Rep Date: 2017-10-03 Impact factor: 9.423

3. Differential expression of T cell-related genes in AMI and SA stages of coronary artery disease.

Authors: Wenwen Yan; Lemin Wang; Jinfa Jiang; Wenjun Xu; Zhu Gong; Qianglin Duan; Chuanrong Li; Haoming Song; Lin Che; Yuqin Shen; Lin Zhou
Journal: Int J Clin Exp Med Date: 2015-07-15

4. Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3⁺CCR4⁺CD8⁺ T Cells That Mediate Rapid Hepatocyte Allograft Rejection.

Authors: Jason M Zimmerer; Bryce A Ringwald; Sachi R Chaudhari; Jing Han; Chelsea M Peterson; Robert T Warren; Madison M Hart; Mahmoud Abdel-Rasoul; Ginny L Bumgardner
Journal: J Immunol Date: 2021-11-22 Impact factor: 5.426

The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis.

1. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

2. Generation of RORγt⁺ Antigen-Specific T Regulatory 17 Cells from Foxp3⁺ Precursors in Autoimmunity.

3. Differential expression of T cell-related genes in AMI and SA stages of coronary artery disease.

4. Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3⁺CCR4⁺CD8⁺ T Cells That Mediate Rapid Hepatocyte Allograft Rejection.

Review 5. The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity.

6. Oryeongsan (Goreisan) Ameliorates Experimental Autoimmune Encephalomyelitis.

7. Chemokine receptor expression by inflammatory T cells in EAE.

Review 8. The role of chemokines and chemokine receptors in multiple sclerosis.

The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis.

1. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

2. Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity.

3. Differential expression of T cell-related genes in AMI and SA stages of coronary artery disease.

4. Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3+CCR4+CD8+ T Cells That Mediate Rapid Hepatocyte Allograft Rejection.

Review 5. The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity.

6. Oryeongsan (Goreisan) Ameliorates Experimental Autoimmune Encephalomyelitis.

7. Chemokine receptor expression by inflammatory T cells in EAE.

Review 8. The role of chemokines and chemokine receptors in multiple sclerosis.

2. Generation of RORγt⁺ Antigen-Specific T Regulatory 17 Cells from Foxp3⁺ Precursors in Autoimmunity.

4. Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3⁺CCR4⁺CD8⁺ T Cells That Mediate Rapid Hepatocyte Allograft Rejection.